The Phenotype analysis integrated associations of neuronal disorders with genes, chemicals and phenotypes from the literature as of January, 2014 (see citation below). This page links the studied disorders to the MeSH database, and make available an alternative representation of the data as a hierarchically clustered heatmap.


  • Fontaine JF, Priller J, Spruth E, Perez-Iratxeta C, Andrade-Navarro MA. Assessment of curated phenotype mining in neuropsychiatric disorder literature. Methods. 2015 Mar;74:90-6. doi: 10.1016/j.ymeth.2014.11.022. Epub 2014 Dec 5. PubMed PMID: 25484337.

Neural Disorders

The following disorders were integrated in the analysis (links go to the MeSH database):

Alzheimer Disease
Amyotrophic Lateral Sclerosis
Bipolar Disorder
Cerebral Amyloid Angiopathy
Corticobasal Degeneration
Depressive Disorder
Down Syndrome
Frontotemporal Dementia
Gaucher Disease
Hepatolenticular Degeneration
Huntington Disease
Leukodystrophy Metachromatic
Lupus Erythematosus Systemic
Motor Neuron Disease
Multiple Sclerosis
Multiple System Atrophy
Muscular Atrophy Spinal
Niemann Pick Disease Type C
Obsessive Compulsive Disorder
Parkinson Disease
REM Sleep Behavior Disorder
Restless Legs Syndrome
Sjogren's Syndrome
Spastic Paraplegia Hereditary
Spinocerebellar Ataxias
Supranuclear Palsy Progressive
Tourette Syndrome

Hierarchical clustering of phenotypes and genes

Heatmap visualization (requires Java plugin).


The hierarchical clustering data is available as a set of 3 files: a CDT (data table), ATR (diseases clustering) and GTR file (features clustering) that may be opened by other software.

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