HIPPO

Evidence for the interaction between CTNB1_HUMAN and APC_HUMAN

Sources

Publications

  • 12000790 (Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.; Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I; 2002)
  • 9482734 (Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.; Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A; 1998)
  • 7890674 (The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.; Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P; 1995)
  • 15327768 (Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.; Ha NC, Tonozuka T, Stamos JL, Choi HJ, Weis WI; 2004)
  • 11166179 (Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.; Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS; 2001)
  • 15327769 (Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.; Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W; 2004)
  • 12628243 (Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein.; Tickenbrock L, Kössmeier K, Rehmann H, Herrmann C, Müller O; 2003)
  • 8259519 (Association of the APC tumor suppressor protein with catenins.; Su LK, Vogelstein B, Kinzler KW; 1993)
  • 11712088 (Expression and interaction of different catenins in colorectal carcinoma cells.; Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V; 2001)
  • 11251183 (The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer.; Davies G, Jiang WG, Mason MD; 2001)
  • 11533658 (Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.; Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP; 2001)
  • 11972058 (Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.; Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y; 2002)
  • 9286858 (DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.; Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T; 1997)
  • 11707392 (Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.; Eklof Spink K, Fridman SG, Weis WI; 2001)
  • 16212417 (Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.; Catimel B, Rothacker J, Catimel J, Faux M, Ross J, Connolly L, Clippingdale A, Burgess AW, Nice E; 2005)
  • 17318191 (Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.; Coluccia AM, Vacca A, Duñach M, Mologni L, Redaelli S, Bustos VH, Benati D, Pinna LA, Gambacorti-Passerini C; 2007)
  • 15355978 (Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.; Choi J, Park SY, Costantini F, Jho EH, Joo CK; 2004)
  • 16510874 (The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.; Sierra J, Yoshida T, Joazeiro CA, Jones KA; 2006)
  • 19576224 (The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.; Huang X, Langelotz C, Hetfeld-Pechoc BK, Schwenk W, Dubiel W; 2009)
  • 22682247 (Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.; Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H; 2012)
  • 21664290 (Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress.; Brocardo MG, Borowiec JA, Henderson BR; 2011)
  • 23840886 (Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.; Schneikert J, Vijaya Chandra SH, Ruppert JG, Ray S, Wenzel EM, Behrens J; 2013)
  • 15525529 (The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.; Hamada F, Bienz M; 2004)
  • 9707618 (A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.; Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K; 1998)
  • 10545404 (Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level.; Hsi LC, Angerman-Stewart J, Eling TE; 1999)
  • 25241761 (Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.; Chen TC, Lin KT, Chen CH, Lee SA, Lee PY, Liu YW, Kuo YL, Wang FS, Lai JM, Huang CY; 2014)
  • 8638126 (Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.; Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P; 1996)
  • 26496610 (A human interactome in three quantitative dimensions organized by stoichiometries and abundances.; Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M; 2015)
  • 27902311 (Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein.; Kuslansky Y, Sominsky S, Jackman A, Gamell C, Monahan BJ, Haupt Y, Rosin-Arbesfeld R, Sherman L; 2016)
  • 29045831 (USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.; Novellasdemunt L, Foglizzo V, Cuadrado L, Antas P, Kucharska A, Encheva V, Snijders AP, Li VSW; 2017)
  • 27684187 (Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.; Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, Hahn WC; 2016)
  • 17510365 (Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.; Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT; 2007)
  • 22056988 (Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.; Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z; 2011)

Experimental systems

TechniquePSI-MI codeScore
Co-crystal Structure1
x-ray crystallographyMI:01141
Reconstituted Complex1
anti bait coimmunoprecipitationMI:00060.5
far western blottingMI:00470.5
tandem affinity purificationMI:06760.5
affinity chromatography technologyMI:00040.5
Affinity Capture-Western0.5
anti tag coimmunoprecipitationMI:00070.5
pull downMI:00960.25
in vivoMI:04930.1
imaging techniqueMI:04280.1
in vitroMI:04920.1

other species

  • Mus musculus (Mouse)
  • Drosophila melanogaster (Fruit fly)