Evidence for the interaction between CTNB1_HUMAN and CADH1_HUMAN



  • 9512503 (E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.; Reuver SM, Garner CC; 1998)
  • 7542250 (Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.; Kinch MS, Clark GJ, Der CJ, Burridge K; 1995)
  • 11226248 (Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.; Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK; 2001)
  • 17057644 (A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.; Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Wolburg H, Ohno S, Behrens J, Vestweber D, Ebnet K; 2006)
  • 17220478 (Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.; Tu LC, Yan X, Hood L, Lin B; 2007)
  • 7954478 (A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.; Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F; 1994)
  • 11245482 (Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.; Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM; 2001)
  • 11254878 (HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells.; Davies G, Jiang WG, Mason MD; 2001)
  • 11712088 (Expression and interaction of different catenins in colorectal carcinoma cells.; Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V; 2001)
  • 9405455 (Vinculin is associated with the E-cadherin adhesion complex.; Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL; 1997)
  • 12061792 (CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells.; Jiang MC, Liao CF, Tai CC; 2002)
  • 9535896 (The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.; Hazan RB, Norton L; 1998)
  • 9819408 (Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.; Li Y, Bharti A, Chen D, Gong J, Kufe D; 1998)
  • 15023525 (Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.; Wendeler MW, Praus M, Jung R, Hecking M, Metzig C, Gessner R; 2004)
  • 12830000 (EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.; Shibata T, Chuma M, Kokubu A, Sakamoto M, Hirohashi S; 2003)
  • 12640114 (p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.; Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M; 2003)
  • 12634428 (Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.; Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS; 2003)
  • 11960376 (UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug.; Oneyama C, Nakano H, Sharma SV; 2002)
  • 8227214 (Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin.; Navarro P, Lozano E, Cano A; 1993)
  • 9233779 (Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence.; Takahashi K, Suzuki K, Tsukatani Y; 1997)
  • 10772923 (MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures.; Dobrosotskaya IY, James GL; 2000)
  • 11113628 (Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.; Geng L, Burrow CR, Li HP, Wilson PD; 2000)
  • 7876318 (Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.; Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M; 1995)
  • 12169098 (Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.; Rao RK, Basuroy S, Rao VU, Karnaky KJ, Gupta A; 2002)
  • 11348595 (The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.; Huber AH, Weis WI; 2001)
  • 10381631 (The fate of E- and P-cadherin during the early stages of apoptosis.; Schmeiser K, Grand RJ; 1999)
  • 18593907 (Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling.; Pai R, Dunlap D, Qing J, Mohtashemi I, Hotzel K, French DM; 2008)
  • 16212417 (Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.; Catimel B, Rothacker J, Catimel J, Faux M, Ross J, Connolly L, Clippingdale A, Burgess AW, Nice E; 2005)
  • 11401320 (FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.; El-Hariry I, Pignatelli M, Lemoine NR; 2001)
  • 9326449 (Loss of density-dependent growth inhibition and dissociation of alpha-catenin from E-cadherin.; Tsukatani Y, Suzuki K, Takahashi K; 1997)
  • 19016843 (Molecular basis of actin reorganization promoted by binding of enterohaemorrhagic Escherichia coli EspB to alpha-catenin.; Hamaguchi M, Hamada D, Suzuki KN, Sakata I, Yanagihara I; 2008)
  • 22158051 (Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties.; Huang Z, Cheng Y, Chiu PM, Cheung FM, Nicholls JM, Kwong DL, Lee AW, Zabarovsky ER, Stanbridge EJ, Lung HL, Lung ML; 2011)
  • 16125672 (Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion.; Xue B, Wen C, Shi Y, Zhao D, Li C; 2005)
  • 22715382 (Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent.; Smyth D, Leung G, Fernando M, McKay DM; 2012)
  • 16574648 (Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion.; Yan HX, Yang W, Zhang R, Chen L, Tang L, Zhai B, Liu SQ, Cao HF, Man XB, Wu HP, Wu MC, Wang HY; 2006)
  • 18593713 (Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.; Tang Y, Liu Z, Zhao L, Clemens TL, Cao X; 2008)
  • 24798214 (Acute and chronic cadmium exposure promotes E-cadherin degradation in MCF7 breast cancer cells.; Ponce E, Louie MC, Sevigny MB; 2014)
  • 22850631 (The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC.; Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R; 2012)
  • 22375065 (Multiple post-translational modifications regulate E-cadherin transport during apoptosis.; Geng F, Zhu W, Anderson RA, Leber B, Andrews DW; 2012)
  • 23180380 (P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model.; Ribeiro AS, Sousa B, Carreto L, Mendes N, Nobre AR, Ricardo S, Albergaria A, Cameselle-Teijeiro JF, Gerhard R, Söderberg O, Seruca R, Santos MA, Schmitt F, Paredes J; 2013)
  • 22752307 (Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis.; Pinheiro H, Carvalho J, Oliveira P, Ferreira D, Pinto MT, Osório H, Licastro D, Bordeira-Carriço R, Jordan P, Lazarevic D, Sanges R, Stupka E, Huntsman D, Seruca R, Oliveira C; 2012)
  • 24424122 (Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA.; Bordeira-Carriço R, Ferreira D, Mateus DD, Pinheiro H, Pêgo AP, Santos MA, Oliveira C; 2014)
  • 25468996 (E-cadherin interactome complexity and robustness resolved by quantitative proteomics.; Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R; 2014)
  • 28966723 (Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.; Vijayakumar S, Liu G, Wen HC, Abu Y, Chong R, Nastri H, Bornstein GG, Pan ZQ, Aaronson SA; 2017)
  • 27684187 (Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.; Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, Hahn WC; 2016)
  • 17909039 (beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells.; Lee HK, Kwak HY, Hur J, Kim IA, Yang JS, Park MW, Yu J, Jeong S; 2007)
  • 25344754 (ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.; Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, Olofsen PA, Moch H, Hancock DC, Downward J, Goldin RD, Zhao J, Tong X, Guo Y, Lu X; 2014)
  • 16983094 (The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.; Peruzzi B, Athauda G, Bottaro DP; 2006)
  • 22056988 (Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.; Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z; 2011)

Experimental systems

TechniquePSI-MI codeScore
surface plasmon resonanceMI:01071
Co-crystal Structure1
x-ray crystallographyMI:01141
fluorescent resonance energy transferMI:00550.6
Affinity Capture-Western0.5
anti tag coimmunoprecipitationMI:00070.5
anti bait coimmunoprecipitationMI:00060.5
affinity chromatography technologyMI:00040.5
pull downMI:00960.25
in vivoMI:04930.1
fluorescence microscopyMI:04160.1
imaging techniqueMI:04280.1
in vitroMI:04920.1

other species

  • Mus musculus (Mouse)