HIPPO

Evidence for the interaction between PSN1_HUMAN and CADH1_HUMAN

Sources

Publications

  • 10635315 (Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts.; Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK; 1999)
  • 11953314 (A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.; Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK; 2002)
  • 11226248 (Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.; Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK; 2001)
  • 16126725 (Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.; Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK; 2005)

Experimental systems

TechniquePSI-MI codeScore
Affinity Capture-Western0.5
affinity chromatography technologyMI:00040.5
coimmunoprecipitationMI:00190.5
in vitroMI:04920.1
in vivoMI:04930.1

other species

  • None