Evidence for the interaction between A4_HUMAN and PSN1_HUMAN



  • 10593990 (Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.; Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM; 1999)
  • 9223340 (Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.; Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ; 1997)
  • 16189514 (Towards a proteome-scale map of the human protein-protein interaction network.; Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M; 2005)
  • 10078972 (Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.; Pradier L, Carpentier N, Delalonde L, Clavel N, Bock MD, Buée L, Mercken L, Tocqué B, Czech C; 1999)
  • 21163940 (Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.; Soler-López M, Zanzoni A, Lluís R, Stelzl U, Aloy P; 2010)
  • 11083918 (X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.; Lau KF, McLoughlin DM, Standen C, Miller CC; 2000)
  • 21115843 (Activation and intrinsic gamma-secretase activity of presenilin 1.; Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM; 2010)

Experimental systems

TechniquePSI-MI codeScore
protease assayMI:04350.75
anti bait coimmunoprecipitationMI:00060.5
affinity chromatography technologyMI:00040.5
in vitroMI:04920.1

other species

  • None