HIPPO

Evidence for the interaction between PSN1_HUMAN and CTNB1_HUMAN

Sources

Publications

  • 9738936 (Direct association of presenilin-1 with beta-catenin.; Murayama M, Tanaka S, Palacino J, Murayama O, Honda T, Sun X, Yasutake K, Nihonmatsu N, Wolozin B, Takashima A; 1998)
  • 10092585 (Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071.; Stahl B, Diehlmann A, Südhof TC; 1999)
  • 12070348 (The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.; Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H; 2002)
  • 11168528 (p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.; Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC; 2001)
  • 16306047 (Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription.; Raurell I, Castaño J, Francí C, García de Herreros A, Duñach M; 2005)
  • 11226248 (Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.; Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK; 2001)
  • 10341227 (Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.; Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH; 1999)
  • 9852041 (Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.; Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE; 1998)
  • 17360711 (A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling.; Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J; 2007)
  • 10037471 (Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.; Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P; 1999)
  • 16126725 (Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.; Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK; 2005)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
Affinity Capture-Western0.5
anti bait coimmunoprecipitationMI:00060.5
affinity chromatography technologyMI:00040.5
coimmunoprecipitationMI:00190.5
pull downMI:00960.25
in vitroMI:04920.1
in vivoMI:04930.1

other species

  • Mus musculus (Mouse)