HIPPO

Evidence for the interaction between TAU_HUMAN and KPCD_HUMAN

Sources

Publications

  • 9771888 (Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.; Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K; 1998)
  • 9735171 (Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.; Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K; 1998)
  • 10090741 (Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.; Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM; 1999)
  • 9832145 (New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.; Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH; 1998)
  • 12387894 (Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.; Liu F, Iqbal K, Grundke-Iqbal I, Gong CX; 2002)
  • 7706316 (Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.; Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E; 1995)
  • 8999860 (The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.; Paudel HK; 1997)
  • 10737616 (Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.; Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH; 2000)
  • 12435421 (Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.; Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX; 0)

Experimental systems

TechniquePSI-MI codeScore
in vitroMI:04920.1

other species

  • None