HIPPO

Evidence for the interaction between PSN1_HUMAN and PSN2_HUMAN

Sources

Publications

  • 12471034 (APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.; Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tandon A, Fraser PE, St George-Hyslop P; 2002)
  • 21163940 (Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.; Soler-López M, Zanzoni A, Lluís R, Stelzl U, Aloy P; 2010)
  • 15474363 (Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.; Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B; 2004)

Experimental systems

TechniquePSI-MI codeScore
Affinity Capture-Western0.5
Two-hybridMI:00180.5
affinity chromatography technologyMI:00040.5

other species

  • None