HIPPO

Evidence for the interaction between IRAK1_HUMAN and NEMO_HUMAN

Sources

Publications

  • 18347055 (Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.; Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD; 2008)
  • 18180283 (Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.; Windheim M, Stafford M, Peggie M, Cohen P; 2008)
  • 17997719 (The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.; Ordureau A, Smith H, Windheim M, Peggie M, Carrick E, Morrice N, Cohen P; 2008)
  • 21220427 (Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.; Xiong Y, Qiu F, Piao W, Song C, Wahl LM, Medvedev AE; 2011)
  • 23104095 (Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.; Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israël L, Trevejo-Nunez G, Bogunovic D, Cepika AM, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debré M, Mazzolari E, Vairo D, Agou F, Virgin HW, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet JC, Pascual V, Chaussabel D, Notarangelo LD, Puel A, Israël A, Casanova JL, Picard C; 2012)
  • 24735611 (Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.; Jeon J, Lee JH, Park KA, Byun HS, Lee H, Lee Y, Zhang T, Kang K, Seok JH, Kwon HJ, Han MD, Kang SW, Hong JH, Hur GM; 2014)
  • 23986494 (Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.; Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P; 2013)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
affinity chromatography technologyMI:00040.5
anti bait coimmunoprecipitationMI:00060.5
Affinity Capture-Western0.5
pull downMI:00960.25

other species

  • None