Evidence for the interaction between NGF_HUMAN and NTRK1_HUMAN



  • 10490030 (Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.; Wiesmann C, Ultsch MH, Bass SH, de Vos AM; 1999)
  • 14985763 (Sortilin is essential for proNGF-induced neuronal cell death.; Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM; 2004)
  • 11729324 (Regulation of cell survival by secreted proneurotrophins.; Lee R, Kermani P, Teng KK, Hempstead BL; 2001)
  • 10713102 (TrkA amino acids controlling specificity for nerve growth factor.; O'Connell L, Hongo JA, Presta LG, Tsoulfas P; 2000)
  • 1849459 (The trk proto-oncogene encodes a receptor for nerve growth factor.; Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M; 1991)
  • 9857023 (A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals.; Saragovi HU, Zheng W, Maliartchouk S, DiGugliemo GM, Mawal YR, Kamen A, Woo SB, Cuello AC, Debeir T, Neet KE; 1998)
  • 9083066 (Two restricted sites on the surface of the nerve growth factor molecule independently determine specific TrkA receptor binding and activation.; Kullander K, Kaplan D, Ebendal T; 1997)
  • 11738045 (Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5.; Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL; 2001)

Experimental systems

TechniquePSI-MI codeScore
surface plasmon resonanceMI:01071
Reconstituted Complex1
x-ray crystallographyMI:01141
Co-crystal Structure1
cross-linking studyMI:00300.5
pull downMI:00960.25
molecular sievingMI:00710.2
in vitroMI:04920.1
in vivoMI:04930.1

other species

  • None