HIPPO

Evidence for the interaction between IRAK1_HUMAN and TRAF6_HUMAN

Sources

Publications

  • 8837778 (TRAF6 is a signal transducer for interleukin-1.; Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV; 1996)
  • 10346818 (Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.; Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M; 1999)
  • 10383454 (IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.; Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z; 1999)
  • 11518704 (IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.; Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X; 2001)
  • 12566447 (Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.; Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J; 2003)
  • 11960013 (IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.; Li S, Strelow A, Fontana EJ, Wesche H; 2002)
  • 10920205 (T6BP, a TRAF6-interacting protein involved in IL-1 signaling.; Ling L, Goeddel DV; 2000)
  • 11259596 (Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.; Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K; 2001)
  • 9374458 (IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.; Muzio M, Ni J, Feng P, Dixit VM; 1997)
  • 18234474 (Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling.; Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D; 2007)
  • 12242293 (Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.; Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X; 2002)
  • 11287640 (IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK).; Li X, Commane M, Jiang Z, Stark GR; 2001)
  • 20043910 (RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.; Tang H, Park S, Sun SC, Trumbly R, Ren G, Tsung E, Yeung KC; 2009)
  • 21220427 (Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.; Xiong Y, Qiu F, Piao W, Song C, Wahl LM, Medvedev AE; 2011)
  • 22033459 (IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.; Muroi M, Tanamoto K; 2011)
  • 22447928 (TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.; Liu A, Gong P, Hyun SW, Wang KZ, Cates EA, Perkins D, Bannerman DD, Puché AC, Toshchakov VY, Fang S, Auron PE, Vogel SN, Goldblum SE; 2012)
  • 11397809 (IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.; Jensen LE, Whitehead AS; 2001)
  • 19716405 (Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling.; Lee JY, Lee HJ, Lee EJ, Jang SH, Kim H, Yoon JH, Chung KC; 2009)
  • 17785851 (Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.; Liu G, Tsuruta Y, Gao Z, Park YJ, Abraham E; 2007)
  • 14625308 (Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.; Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, Li S, Wesche H, Martin MU; 2003)
  • 18056395 (Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).; Lakshmanan U, Porter AG; 2007)
  • 12496252 (Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.; Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X; 2002)
  • 16951688 (Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.; Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH; 2006)
  • 19166926 (Regulation of IRAK-1 activation by its C-terminal domain.; Nguyen T, De Nardo D, Masendycz P, Hamilton JA, Scholz GM; 2009)
  • 16024789 (A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.; Rao N, Nguyen S, Ngo K, Fung-Leung WP; 2005)
  • 23381138 (UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.; Zhang X, Zhang J, Zhang L, van Dam H, ten Dijke P; 2013)
  • 17197697 (Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.; Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X; 2006)
  • 23244239 (PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation.; Lee HJ, Chung KC; 2012)
  • 24735611 (Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.; Jeon J, Lee JH, Park KA, Byun HS, Lee H, Lee Y, Zhang T, Kang K, Seok JH, Kwon HJ, Han MD, Kang SW, Hong JH, Hur GM; 2014)
  • 24434549 (TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.; Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB; 2014)
  • 18347055 (Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.; Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD; 2008)
  • 28882891 (Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.; Tanishima M, Takashima S, Honda A, Yasuda D, Tanikawa T, Ishii S, MaruYama T; 2017)

Experimental systems

TechniquePSI-MI codeScore
Affinity Capture-Western0.5
anti tag coimmunoprecipitationMI:00070.5
coimmunoprecipitationMI:00190.5
Two-hybridMI:00180.5
anti bait coimmunoprecipitationMI:00060.5
affinity chromatography technologyMI:00040.5
pull downMI:00960.25
in vivoMI:04930.1
in vitroMI:04920.1
enzymatic studyMI:04150.1

other species

  • Mus musculus (Mouse)