Evidence for the interaction between IRAK1_HUMAN and IRAK4_HUMAN



  • 11960013 (IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.; Li S, Strelow A, Fontana EJ, Wesche H; 2002)
  • 12860405 (Characterization of Pellino2, a substrate of IRAK1 and IRAK4.; Strelow A, Kollewe C, Wesche H; 2003)
  • 18221795 (MAPPIT analysis of early Toll-like receptor signalling events.; Ulrichts P, Tavernier J; 2008)
  • 21903422 (Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.; Li S, Wang L, Berman M, Kong YY, Dorf ME; 2011)
  • 16951688 (Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.; Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH; 2006)
  • 17785851 (Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.; Liu G, Tsuruta Y, Gao Z, Park YJ, Abraham E; 2007)
  • 17276401 (The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.; Neumann D, Kollewe C, Resch K, Martin MU; 2007)
  • 19166926 (Regulation of IRAK-1 activation by its C-terminal domain.; Nguyen T, De Nardo D, Masendycz P, Hamilton JA, Scholz GM; 2009)
  • 12538665 (Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.; Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J; 2003)
  • 16024789 (A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.; Rao N, Nguyen S, Ngo K, Fung-Leung WP; 2005)
  • 24735611 (Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.; Jeon J, Lee JH, Park KA, Byun HS, Lee H, Lee Y, Zhang T, Kang K, Seok JH, Kwon HJ, Han MD, Kang SW, Hong JH, Hur GM; 2014)

Experimental systems

TechniquePSI-MI codeScore
anti tag coimmunoprecipitationMI:00070.5
Biochemical Activity0.5
protein complementation assayMI:00900.5
Affinity Capture-Western0.5
affinity chromatography technologyMI:00040.5
in vivoMI:04930.1
enzymatic studyMI:04150.1
in vitroMI:04920.1

other species

  • None