Evidence for the interaction between NOTC3_HUMAN and JAG1_HUMAN



  • 14714274 (Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.; Joutel A, Monet M, Domenga V, Riant F, Tournier-Lasserve E; 2004)
  • 12482954 (A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.; Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J; 2002)
  • 11006133 (Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.; Shimizu K, Chiba S, Saito T, Kumano K, Hirai H; 2000)
  • 22487239 (Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome.; Tada M, Itoh S, Ishii-Watabe A, Suzuki T, Kawasaki N; 2012)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
anti tag coimmunoprecipitationMI:00070.5
pull downMI:00960.25
in vivoMI:04930.1
in vitroMI:04920.1

other species

  • None