HIPPO

Evidence for the interaction between PGFRB_HUMAN and P85A_HUMAN

Sources

Publications

  • 10697503 (GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells.; Farooqui T, Kelley T, Coggeshall KM, Rampersaud AA, Yates AJ; 1999)
  • 1372092 (SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.; McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A; 1992)
  • 7486683 (Common and distinct elements in insulin and PDGF signaling.; Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF; 1995)
  • 16713569 (A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.; Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY; 2006)
  • 8670861 (Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.; Breeze AL, Kara BV, Barratt DG, Anderson M, Smith JC, Luke RW, Best JR, Cartlidge SA; 1996)
  • 11710529 (Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins.; Park D, Yun Y; 2001)
  • 8564419 (Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor.; Ramalingam K, Eaton SR, Cody WL, Lu GH, Panek RL, Waite LA, Decker SJ, Keiser JA, Doherty AM; 1995)
  • 10752619 (Alternative modes of binding of proteins with tandem SH2 domains.; O'Brien R, Rugman P, Renzoni D, Layton M, Handa R, Hilyard K, Waterfield MD, Driscoll PC, Ladbury JE; 2000)
  • 7692233 (Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.; Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J; 1993)
  • 9153411 (Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands.; Gay B, Furet P, García-Echeverría C, Rahuel J, Chène P, Fretz H, Schoepfer J, Caravatti G; 1997)
  • 8382612 (Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.; Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA; 1993)
  • 7680644 (A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding.; Williams KP, Shoelson SE; 1993)
  • 7536927 (Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.; Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J; 1995)
  • 11896612 (Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.; Saucier C, Papavasiliou V, Palazzo A, Naujokas MA, Kremer R, Park M; 2002)
  • 1330535 (Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.; Panayotou G, Bax B, Gout I, Federwisch M, Wroblowski B, Dhand R, Fry MJ, Blundell TL, Wollmer A, Waterfield MD; 1992)
  • 1314164 (Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.; Kashishian A, Kazlauskas A, Cooper JA; 1992)
  • 15377662 (The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.; Chamberlain MD, Berry TR, Pastor MC, Anderson DH; 2004)
  • 16135792 (Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.; Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T; 2005)
  • 19864249 (High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation.; Leuchowius KJ, Jarvius M, Wickström M, Rickardson L, Landegren U, Larsson R, Söderberg O, Fryknäs M, Jarvius J; 2009)
  • 28514442 (Architecture of the human interactome defines protein communities and disease networks.; Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW; 2017)

Experimental systems

TechniquePSI-MI codeScore
nuclear magnetic resonanceMI:00771
isothermal titration calorimetryMI:00651
surface plasmon resonanceMI:01071
circular dichroismMI:00160.9
classical fluorescence spectroscopyMI:00170.75
affinity chromatography technologyMI:00040.5
Two-hybridMI:00180.5
coimmunoprecipitationMI:00190.5
Affinity Capture-Western0.5
cross-linking studyMI:00300.5
pull downMI:00960.25
in vivoMI:04930.1

other species

  • None