Evidence for the interaction between GATA4_HUMAN and NKX25_HUMAN



  • 9312027 (The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.; Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M; 1997)
  • 10948187 (Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.; Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I; 2000)
  • 12845333 (GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.; Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D; 2003)
  • 15542826 (Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.; Kim TG, Chen J, Sadoshima J, Lee Y; 2004)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
Affinity Capture-Western0.5
affinity chromatography technologyMI:00040.5
pull downMI:00960.25
in vitroMI:04920.1
in vivoMI:04930.1

other species

  • Mus musculus (Mouse)