Evidence for the interaction between PK3CA_HUMAN and RASH_HUMAN



  • 9150145 (Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.; Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J; 1997)
  • 14724584 (The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.; Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J; 2004)
  • 10783161 (The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.; Li W, Han M, Guan KL; 2000)
  • 8665852 (Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.; Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J; 1996)
  • 24412244 (Charting the molecular links between driver and susceptibility genes in colorectal cancer.; Arroyo R, Duran-Frigola M, Berenguer C, Soler-López M, Aloy P; 2014)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
pull downMI:00960.25
in vivoMI:04930.1

other species

  • Drosophila melanogaster (Fruit fly) ( 1 , 2 , 3 )