Evidence for the interaction between TERA_HUMAN and ATX3_HUMAN



  • 12944474 (Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis.; Doss-Pepe EW, Stenroos ES, Johnson WG, Madura K; 2003)
  • 16525503 (An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.; Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE; 2006)
  • 18199748 (Inhibition of p97-dependent protein degradation by Eeyarestatin I.; Wang Q, Li L, Ye Y; 2008)
  • 16713569 (A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.; Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY; 2006)
  • 20414249 (Imbalances in p97 co-factor interactions in human proteinopathy.; Fernández-Sáiz V, Buchberger A; 2010)
  • 14749733 (Molecular clearance of ataxin-3 is regulated by a mammalian E4.; Matsumoto M, Yada M, Hatakeyama S, Ishimoto H, Tanimura T, Tsuji S, Kakizuka A, Kitagawa M, Nakayama KI; 2004)
  • 16822850 (Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.; Zhong X, Pittman RN; 2006)
  • 19843543 (Proteotoxic stress increases nuclear localization of ataxin-3.; Reina CP, Zhong X, Pittman RN; 2009)
  • 22970133 (Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.; Laço MN, Cortes L, Travis SM, Paulson HL, Rego AC; 2012)
  • 19175675 (Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.; Morreale G, Conforti L, Coadwell J, Wilbrey AL, Coleman MP; 2009)
  • 23383273 (VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.; Yu CC, Yang JC, Chang YC, Chuang JG, Lin CW, Wu MS, Chow LP; 2013)
  • 24100225 (Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP.; Liu S, Fu QS, Zhao J, Hu HY; 2013)
  • 25231079 (Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology.; Yang H, Li JJ, Liu S, Zhao J, Jiang YJ, Song AX, Hu HY; 2014)
  • 27762274 (Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.; Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE; 2016)
  • 28275011 (Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.; Pfeiffer A, Luijsterburg MS, Acs K, Wiegant WW, Helfricht A, Herzog LK, Minoia M, Böttcher C, Salomons FA, van Attikum H, Dantuma NP; 2017)
  • 27851749 (The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.; Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS; 2016)
  • 28180282 (Ataxin-3 promotes genome integrity by stabilizing Chk1.; Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C, Tang TS; 2017)

Experimental systems

TechniquePSI-MI codeScore
x-ray crystallographyMI:01141
competition bindingMI:04050.5
affinity chromatography technologyMI:00040.5
anti tag coimmunoprecipitationMI:00070.5
peptide arrayMI:00810.5
Affinity Capture-Western0.5
gst pull downMI:00590.5
filter bindingMI:00490.5
anti bait coimmunoprecipitationMI:00060.5
pull downMI:00960.25
cosedimentation in solutionMI:00280.2
cosedimentation through density gradientMI:00290.2
in vitroMI:04920.1
colocalization by immunostainingMI:00220.1
imaging techniqueMI:04280.1
fluorescence microscopyMI:04160.1

other species

  • Mus musculus (Mouse) ( 1 )
  • Caenorhabditis elegans