Evidence for the interaction between P63_HUMAN and ITCH_HUMAN



  • 16908849 (The E3 ubiquitin ligase Itch controls the protein stability of p63.; Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM, Melino G; 2006)
  • 20855944 (Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant.; Bellomaria A, Barbato G, Melino G, Paci M, Melino S; 2010)
  • 22935697 (Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction.; Bellomaria A, Barbato G, Melino G, Paci M, Melino S; 2012)
  • 23370280 (Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy.; Salah Z, Bar-mag T, Kohn Y, Pichiorri F, Palumbo T, Melino G, Aqeilan RI; 2013)
  • 25485500 (p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch.; Melino S, Bellomaria A, Nepravishta R, Paci M, Melino G; 0)

Experimental systems

TechniquePSI-MI codeScore
x-ray crystallographyMI:01141
affinity chromatography technologyMI:00040.5
anti bait coimmunoprecipitationMI:00060.5
anti tag coimmunoprecipitationMI:00070.5
pull downMI:00960.25

other species

  • None