HIPPO

Evidence for the interaction between CASP8_HUMAN and FADD_HUMAN

Sources

Publications

  • 12107169 (Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen.; Thomas LR, Stillman DJ, Thorburn A; 2002)
  • 11717445 (Caspase-10 is an initiator caspase in death receptor signaling.; Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ; 2001)
  • 8681376 (Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.; Boldin MP, Goncharov TM, Goltsev YV, Wallach D; 1996)
  • 17159907 (Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.; Feig C, Tchikov V, Schütze S, Peter ME; 2006)
  • 17290218 (Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.; Yao Z, Duan S, Hou D, Heese K, Wu M; 2007)
  • 15659383 (Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.; Gajate C, Mollinedo F; 2005)
  • 12887920 (Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.; Micheau O, Tschopp J; 2003)
  • 9228018 (FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.; Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES; 1997)
  • 12911633 (Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.; Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP; 2003)
  • 19060883 (ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.; Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A; 2008)
  • 14612908 (Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells.; Curtin JF, Cotter TG; 2003)
  • 18485876 (TNF-alpha induces two distinct caspase-8 activation pathways.; Wang L, Du F, Wang X; 2008)
  • 19524512 (Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.; He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X; 2009)
  • 21458669 (NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling.; Biton S, Ashkenazi A; 2011)
  • 21525013 (TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.; Ikner A, Ashkenazi A; 2011)
  • 21785459 (DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.; Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G; 2011)
  • 17047155 (Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.; Rébé C, Cathelin S, Launay S, Filomenko R, Prévotat L, L'Ollivier C, Gyan E, Micheau O, Grant S, Dubart-Kupperschmitt A, Fontenay M, Solary E; 2006)
  • 21620750 (Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor.; Ramakrishnan P, Baltimore D; 2011)
  • 21737329 (The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.; Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P; 2011)
  • 20448643 (Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation.; Won M, Park KA, Byun HS, Sohn KC, Kim YR, Jeon J, Hong JH, Park J, Seok JH, Kim JM, Yoon WH, Jang IS, Shen HM, Liu ZG, Hur GM; 2010)
  • 22179575 (De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.; Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, AbuAli G, Lin B, Grimm S; 2011)
  • 20103630 (Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.; Pavet V, Beyrath J, Pardin C, Morizot A, Lechner MC, Briand JP, Wendland M, Maison W, Fournel S, Micheau O, Guichard G, Gronemeyer H; 2010)
  • 22173242 (RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis.; Löder S, Fakler M, Schoeneberger H, Cristofanon S, Leibacher J, Vanlangenakker N, Bertrand MJ, Vandenabeele P, Jeremias I, Debatin KM, Fulda S; 2011)
  • 21988832 (Toward an understanding of the protein interaction network of the human liver.; Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X; 2011)
  • 22274400 (Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis.; Feoktistova M, Geserick P, Panayotova-Dimitrova D, Leverkus M; 2012)
  • 14681455 (IntAct: an open source molecular interaction database.; Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, Margalit H, Armstrong J, Bairoch A, Cesareni G, Sherman D, Apweiler R; 2004)
  • 12702723 (Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex.; Ryu SW, Lee SJ, Park MY, Jun JI, Jung YK, Kim E; 2003)
  • 15280356 (Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.; Sinha SK, Chaudhary PM; 2004)
  • 19176810 (The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.; Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT; 2009)
  • 23142077 (TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.; Gonzalvez F, Lawrence D, Yang B, Yee S, Pitti R, Marsters S, Pham VC, Stephan JP, Lill J, Ashkenazi A; 2012)
  • 22864571 (Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis.; Lee EW, Kim JH, Ahn YH, Seo J, Ko A, Jeong M, Kim SJ, Ro JY, Park KM, Lee HW, Park EJ, Chun KH, Song J; 0)
  • 23972990 (Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.; Puliyappadamba VT, Chakraborty S, Chauncey SS, Li L, Hatanpaa KJ, Mickey B, Noorani S, Shu HK, Burma S, Boothman DA, Habib AA; 2013)
  • 21737330 (cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.; Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M; 2011)
  • 25939870 (ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly.; Selmi T, Alecci C, dell' Aquila M, Montorsi L, Martello A, Guizzetti F, Volpi N, Parenti S, Ferrari S, Salomoni P, Grande A, Zanocco-Marani T; 2015)
  • 20829884 (Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.; Choi H, Chang JW, Jung YK; 2010)
  • 25043603 (Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.; Graves JD, Kordich JJ, Huang TH, Piasecki J, Bush TL, Sullivan T, Foltz IN, Chang W, Douangpanya H, Dang T, O'Neill JW, Mallari R, Zhao X, Branstetter DG, Rossi JM, Long AM, Huang X, Holland PM; 2014)
  • 25911380 (The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis.; Yamaguchi N, Yamaguchi N; 2015)
  • 9343261 (Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.; Wang GH, Bertin J, Wang Y, Martin DA, Wang J, Tomaselli KJ, Armstrong RC, Cohen JI; 1997)
  • 27321185 (USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.; Jeong M, Lee EW, Seong D, Seo J, Kim JH, Grootjans S, Kim SY, Vandenabeele P, Song J; 2016)
  • 26437781 (A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.; Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsunomiya A, Watanabe T, Yamaoka S; 2015)
  • 29497034 (Proteasome inhibition blocks necroptosis by attenuating death complex aggregation.; Ali M, Mocarski ES; 2018)
  • 24098568 (CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.; Moquin DM, McQuade T, Chan FK; 2013)
  • 27552911 (Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.; Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F; 2016)
  • 26972597 (FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis.; Ranjan K, Pathak C; 2016)
  • 27560715 (NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.; Pescatore A, Esposito E, Draber P, Walczak H, Ursini MV; 2016)
  • 23955153 (Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.; Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F; 2013)

Experimental systems

TechniquePSI-MI codeScore
Reconstituted Complex1
fluorescent resonance energy transferMI:00550.6
affinity chromatography technologyMI:00040.5
Two-hybridMI:00180.5
Affinity Capture-Western0.5
anti bait coimmunoprecipitationMI:00060.5
anti tag coimmunoprecipitationMI:00070.5
pull downMI:00960.25
copurificationMI:00250.2
cosedimentation through density gradientMI:00290.2
in vivoMI:04930.1
inferred by curatorMI:03640.1
in vitroMI:04920.1

other species

  • Rattus norvegicus (Rat)
  • Mus musculus (Mouse)