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iOrME

v1.0

insect Odorant Receptors Molecular Evolution

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What are ORs? Insect Odorant Receptors (ORs) are transmembrane proteins (7TM) that dimerize with Orco to form a channel sensitive to a ligand. The ligand is an odorant (volatile chemical) that triggers a neuronal response. See here for more information.

What is the purpose of this repository? We are trying to collect good quality sequences of complete sets of ORs from species with completely sequenced genomes. The dataset should be useful for research on the functionality and evolution of insect perception and behavior, and for the development of chemicals for pest control.

How was the curation process done? Sequences identified as pseudogenes or fragments were removed. After multiple sequence alignment with ORs from our collection, sequences showing large and unique insertions and deletions, or large stretches with low conservation compared to the aligned sequences, were entirely removed.

What did we do with the curated OR sequences? We clustered the sequences based on their sequence similarity, using OrthoFinder. These clusters are aimed to facilitate the characterization of the evolutionary history of the OR protein family, and to evaluate the relation between similarity in sequence features and biological properties.

How much information is currently in iOrME? By December 2021, we have curated OR data for 21 insect species. This is a total of 3902 sequences, divided in 206 clusters.

How to cite us? Mier P, Stoldt M, Fontaine JF, Libbrecht R, Martelli C, Foitzik S, Andrade-Navarro MA. Functional characterization of odorant receptor genes in solitary and social insects using machine learning. Genes, 13:919. PMID:35627304.


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OR sequences (raw)OR sequences (curated)Clusters
4708 ORs logo 3902 ORs logo 206 clusters logo

OR SEQUENCES
Species TaxID Taxonomy
[Order > Suborder > Family]
Number OR
(raw)
Fasta [PMID] Number OR
(curated)
Fasta [Curator] Updated
Drosophila melanogaster 7227 Diptera > Brachycera > Drosophilidae 61 logo [14608037] 61 logo [MAAN] 10/2021
Anopheles gambiae 7165 Diptera > Nematocera > Culicidae 79 logo [20130575] 73 logo [MAAN] 10/2021
Apis mellifera 7460 Hymenoptera > Apocrita > Apidae 160 logo [30249741] 153 logo [MAAN] 10/2021
Solenopsis invicta 13686 Hymenoptera > Apocrita > Formicidae 396 logo [30249741] 287 logo [MAAN] 10/2021
Pogonomyrmex barbatus 144034 Hymenoptera > Apocrita > Formicidae 293 logo [21282651] 293 logo [MAAN] 10/2021
Ooceraea biroi 2015173 Hymenoptera > Apocrita > Formicidae 574 logo [30249741] 501 logo [MAAN] 10/2021
Nasonia vitripennis 7425 Hymenoptera > Apocrita > Pteromalidae 211 logo [30249741] 199 logo [MAAN] 10/2021
Atta cephalotes 12957 Hymenoptera > Apocrita > Formicidae 434 logo [26306879] 281 logo [MAAN] 10/2021
Acromyrmex echinatior 103372 Hymenoptera > Apocrita > Formicidae 435 logo [26306879] 306 logo [MAAN] 10/2021
Camponotus floridanus 104421 Hymenoptera > Apocrita > Formicidae 407 logo [22952454] 376 logo [MAAN] 10/2021
Harpegnathos saltator 610380 Hymenoptera > Apocrita > Formicidae 377 logo [22952454] 360 logo [MAAN] 10/2021
Linepithema humile 83485 Hymenoptera > Apocrita > Formicidae 367 logo [21282631] 323 logo [MAAN] 10/2021
Blattella germanica 6973 Blattodea > - > Ectobiidae 135 logo [29566459] 89 logo [MAAN] 10/2021
Calopteryx splendens 52612 Odonata > Zygoptera > Calopterygidae 5 logo [28137743] 5 logo [MAAN] 10/2021
Bombus terrestris 30195 Hymenoptera > Apocrita > Apidae 165 logo [25908251] 149 logo [MAAN] 10/2021
Tribolium castaneum 7070 Coleoptera > Polyphaga > Tenebrionidae 338 logo [18362917] 253 logo [MAAN] 10/2021
Cloeon dipterum 197152 Ephemeroptera > Pisciforma > Baetidae 50 logo [32457347] 24 logo [MAAN] 10/2021
Manduca sexta 7130 Lepidoptera > Glossata > Sphingidae 74 logo [26365739] 50 logo [MAAN] 10/2021
Pediculus humanus 121224 Phthiraptera > Anoplura > Pediculidae 13 logo [20566863] 10 logo [MAAN] 10/2021
Acyrthosiphon pisum 7029 Hemiptera > Sternorrhyncha > Aphididae 87 logo [30654011] 67 logo [MAAN] 10/2021
Aphis glycines 307491 Hemiptera > Sternorrhyncha > Aphididae 47 logo [30654011] 42 logo [MAAN] 10/2021

CLUSTERS
ID Number OR Protein length Number species Common taxonomy
logo Last common taxa between all species represented in the cluster
Conservation score
logo Mean conservation ratio of the most frequent amino acid per position when aligning the sequences in the cluster (range = 0-1). Only calculated for clusters with >=5 ORs
Ratio predictive/bg
logo Ratio between the mean conservation score of the top predictive amino acids detected by our Machine Learning algorithm and the conservation score of the complete sequence. Only calculated for clusters with >=5 ORs
Social ratio
logo Ratio of proteins from social insects in cluster
Sequences Excerpt from aln
C0589390.26 ± 26.0121Insecta0.3550.8480.633 logologo
C1481403.87 ± 7.9115Neoptera0.4870.9430.952 logologo
C2277391.91 ± 4.468Formicoidea0.5930.9901.000 logologo
C3260385.87 ± 11.2418Insecta0.5340.9530.935 logologo
C4190392.72 ± 8.5910Neoptera0.5040.9050.874 logologo
C5154395.36 ± 13.1013Neoptera0.4681.0210.721 logologo
C6138406.26 ± 44.1221Insecta0.2980.8960.551 logologo
C7126395.02 ± 7.1414Neoptera0.5710.9790.921 logologo
C889374.20 ± 3.2311Hymenoptera0.5170.8940.989 logologo
C986394.48 ± 2.878Endopterygota0.6280.9620.988 logologo
C1056397.09 ± 2.7310Aculeata0.6281.0451.000 logologo
C1143394.26 ± 3.868Formicoidea0.6470.9471.000 logologo
C1242390.45 ± 8.6210Hymenoptera0.4741.0360.548 logologo
C1342393.86 ± 8.326Hymenoptera0.6620.9430.929 logologo
C1437394.38 ± 3.861Ooceraea biroi0.8191.0381.000 logologo
C1536408.75 ± 34.809Neoptera0.6611.0470.972 logologo
C1635384.40 ± 6.331Tribolium castaneum0.6800.9590.000 logologo
C1733425.36 ± 14.745Neoptera0.6350.9610.000 logologo
C1833382.36 ± 10.351Tribolium castaneum0.5250.9790.000 logologo
C1932403.94 ± 21.8011Insecta0.5950.9870.844 logologo
C2029390.48 ± 2.899Hymenoptera0.7071.0230.966 logologo
C2128394.36 ± 7.3810Endopterygota0.5550.9370.821 logologo
C2228384.11 ± 3.788Formicoidea0.7241.0121.000 logologo
C2324400.17 ± 7.229Aculeata0.6890.9931.000 logologo
C2423389.30 ± 5.809Hymenoptera0.5810.9450.957 logologo
C2523387.78 ± 5.491Tribolium castaneum0.4490.9200.000 logologo
C2622406.23 ± 4.8812Endopterygota0.7561.0490.909 logologo
C2722390.14 ± 6.787Formicoidea0.7010.9271.000 logologo
C2822373.14 ± 14.525Aculeata0.5990.9551.000 logologo
C2922409.86 ± 11.014Neoptera0.5380.9960.000 logologo
C3021408.00 ± 18.556Neoptera0.4750.9870.095 logologo
C3120374.70 ± 5.809Hymenoptera0.4821.0520.750 logologo
C3220395.30 ± 0.571Ooceraea biroi0.8241.0501.000 logologo
C3319384.79 ± 11.853Neoptera0.7351.0000.947 logologo
C3418391.28 ± 1.458Formicoidea0.6841.0041.000 logologo
C3517383.12 ± 4.951Tribolium castaneum0.5410.9650.000 logologo
C3616399.00 ± 6.096Formicoidea0.7160.9091.000 logologo
C3716394.56 ± 2.101Ooceraea biroi0.8241.0351.000 logologo
C3815392.73 ± 16.0310Neoptera0.6491.0200.800 logologo
C3914410.07 ± 22.034Neoptera0.4851.0560.000 logologo
C4014397.71 ± 3.896Formicoidea0.7020.9791.000 logologo
C4114395.43 ± 1.791Ooceraea biroi0.8201.0231.000 logologo
C4213394.85 ± 1.347Formicoidea0.7140.8941.000 logologo
C4313391.69 ± 2.328Aculeata0.6460.9231.000 logologo
C4413398.00 ± 2.867Formicoidea0.8000.9411.000 logologo
C4513393.85 ± 4.165Formicoidea0.7360.9841.000 logologo
C4612396.58 ± 10.774Neoptera0.4590.9080.000 logologo
C4711398.18 ± 1.1711Endopterygota0.7430.9740.909 logologo
C4811394.00 ± 6.488Endopterygota0.6530.9800.818 logologo
C4911390.27 ± 5.619Hymenoptera0.7260.9660.909 logologo
C5011400.91 ± 8.343Endopterygota0.6811.0340.909 logologo
C5110377.10 ± 5.598Formicoidea0.8000.9711.000 logologo
C5210417.30 ± 9.719Endopterygota0.6751.0430.800 logologo
C5310401.90 ± 9.158Hymenoptera0.6390.9200.900 logologo
C5410400.20 ± 2.105Formicoidea0.7981.0241.000 logologo
C5510393.10 ± 5.115Endopterygota0.5660.9630.700 logologo
C569403.33 ± 4.248Formicoidea0.7370.9441.000 logologo
C579383.33 ± 7.716Formicoidea0.8541.0461.000 logologo
C589397.00 ± 0.876Formicoidea0.8540.9751.000 logologo
C599398.00 ± 2.187Formicoidea0.7861.0601.000 logologo
C609386.78 ± 3.152Diptera0.6111.0000.000 logologo
C619401.00 ± 20.543Neoptera0.5971.1490.778 logologo
C629370.00 ± 5.291Tribolium castaneum0.6121.0110.000 logologo
C639377.78 ± 8.901Tribolium castaneum0.6650.9310.000 logologo
C648396.38 ± 1.306Formicoidea0.8001.0411.000 logologo
C658393.38 ± 2.836Formicoidea0.6710.9551.000 logologo
C668406.62 ± 33.318Neoptera0.7601.0260.875 logologo
C678394.75 ± 8.225Hymenoptera0.6330.9240.500 logologo
C688372.25 ± 7.151Tribolium castaneum0.6360.8980.000 logologo
C697383.86 ± 6.266Formicoidea0.7820.9721.000 logologo
C707386.00 ± 4.007Formicoidea0.8320.9691.000 logologo
C717400.57 ± 7.046Formicoidea0.7110.9691.000 logologo
C727390.00 ± 0.582Apoidea0.7530.9751.000 logologo
C737399.71 ± 2.931Ooceraea biroi0.8461.0061.000 logologo
C747394.57 ± 1.131Ooceraea biroi0.9000.9991.000 logologo
C757395.71 ± 0.491Ooceraea biroi0.8970.9891.000 logologo
C766392.33 ± 2.425Formicoidea0.7250.9701.000 logologo
C776412.67 ± 4.231Anopheles gambiae0.4451.0040.000 logologo
C786372.17 ± 3.601Acyrthosiphon pisum0.8771.0270.000 logologo
C796411.33 ± 19.502Neoptera0.6780.9040.000 logologo
C806463.67 ± 2.341Blattella germanica0.7840.9730.000 logologo
C816374.00 ± 26.823Insecta0.4430.9320.000 logologo
C826388.33 ± 3.984Formicoidea0.8460.9691.000 logologo
C836391.50 ± 0.841Linepithema humile0.7510.9801.000 logologo
C846401.67 ± 7.031Nasonia vitripennis0.7201.0740.000 logologo
C856381.17 ± 8.911Nasonia vitripennis0.4900.9730.000 logologo
C865391.80 ± 2.284Formicoidea0.7270.9631.000 logologo
C875391.00 ± 5.435Formicoidea0.8060.9931.000 logologo
C885380.00 ± 15.173Endopterygota0.6190.9920.600 logologo
C895409.40 ± 29.553Neoptera0.5970.9510.000 logologo
C905407.80 ± 1.792Apoidea0.8101.0061.000 logologo
C915380.00 ± 2.242Neoptera0.7280.9750.000 logologo
C925359.20 ± 26.402Insecta0.5840.9910.200 logologo
C935392.80 ± 9.521Camponotus floridanus0.7911.0011.000 logologo
C945391.00 ± 0.001Linepithema humile0.8871.0111.000 logologo
C955399.80 ± 2.171Manduca sexta0.6080.9870.000 logologo
C965395.60 ± 1.342Endopterygota0.7430.9310.800 logologo
C975392.00 ± 2.001Ooceraea biroi0.8700.9771.000 logologo
C985393.80 ± 1.101Solenopsis invicta0.8651.0121.000 logologo
C995374.20 ± 0.841Tribolium castaneum0.7820.9920.000 logologo
C1005383.20 ± 2.491Tribolium castaneum0.7000.9490.000 logologo
C1014396.50 ± 2.524Formicoidea--1.000 logologo
C1024409.75 ± 18.573Neoptera--0.000 logologo
C1034479.75 ± 7.411Blattella germanica--0.000 logologo
C1044393.75 ± 0.501Camponotus floridanus--1.000 logologo
C1054402.75 ± 3.303Formicoidea--1.000 logologo
C1064392.00 ± 1.414Formicoidea--1.000 logologo
C1074399.75 ± 1.501Ooceraea biroi--1.000 logologo
C1084395.25 ± 0.501Ooceraea biroi--1.000 logologo
C1094392.00 ± 0.001Ooceraea biroi--1.000 logologo
C1104392.50 ± 2.651Solenopsis invicta--1.000 logologo
C1114400.25 ± 1.501Solenopsis invicta--1.000 logologo
C1124381.75 ± 1.501Tribolium castaneum--0.000 logologo
C1134391.75 ± 1.501Tribolium castaneum--0.000 logologo
C1144361.25 ± 3.861Tribolium castaneum--0.000 logologo
C1154388.75 ± 6.451Tribolium castaneum--0.000 logologo
C1163390.67 ± 7.772Diptera--0.000 logologo
C1173408.00 ± 3.462Apoidea--1.000 logologo
C1183369.67 ± 0.583Formicoidea--1.000 logologo
C1193388.33 ± 1.153Formicoidea--1.000 logologo
C1203387.67 ± 3.211Camponotus floridanus--1.000 logologo
C1213411.00 ± 5.571Drosophila melanogaster--0.000 logologo
C1223398.67 ± 13.581Harpegnathos saltator--1.000 logologo
C1233391.67 ± 6.113Formicoidea--1.000 logologo
C1243387.00 ± 0.001Linepithema humile--1.000 logologo
C1253406.00 ± 0.001Linepithema humile--1.000 logologo
C1263409.00 ± 0.001Nasonia vitripennis--0.000 logologo
C1273407.33 ± 0.581Nasonia vitripennis--0.000 logologo
C1283402.33 ± 4.041Nasonia vitripennis--0.000 logologo
C1293395.67 ± 1.531Ooceraea biroi--1.000 logologo
C1303391.00 ± 0.001Ooceraea biroi--1.000 logologo
C1313393.67 ± 1.531Ooceraea biroi--1.000 logologo
C1323401.00 ± 1.731Ooceraea biroi--1.000 logologo
C1333399.00 ± 0.001Ooceraea biroi--1.000 logologo
C1343393.67 ± 0.581Ooceraea biroi--1.000 logologo
C1353387.00 ± 14.181Tribolium castaneum--0.000 logologo
C1363376.67 ± 14.571Tribolium castaneum--0.000 logologo
C1373397.00 ± 18.191Tribolium castaneum--0.000 logologo
C1382379.00 ± 0.002Attini--1.000 logologo
C1392401.50 ± 2.122Apoidea--1.000 logologo
C1402403.00 ± 0.001Bombus terrestris--1.000 logologo
C1412376.00 ± 1.411Bombus terrestris--1.000 logologo
C1422382.00 ± 0.001Camponotus floridanus--1.000 logologo
C1432400.50 ± 3.541Camponotus floridanus--1.000 logologo
C1442390.50 ± 7.781Camponotus floridanus--1.000 logologo
C1452393.00 ± 0.001Drosophila melanogaster--0.000 logologo
C1462389.00 ± 2.831Harpegnathos saltator--1.000 logologo
C1472388.50 ± 0.712Formicoidea--1.000 logologo
C1482431.00 ± 0.001Manduca sexta--0.000 logologo
C1492406.50 ± 3.541Manduca sexta--0.000 logologo
C1502412.00 ± 5.661Manduca sexta--0.000 logologo
C1512390.00 ± 11.311Manduca sexta--0.000 logologo
C1522387.00 ± 1.411Manduca sexta--0.000 logologo
C1532401.50 ± 0.711Nasonia vitripennis--0.000 logologo
C1542395.50 ± 0.711Nasonia vitripennis--0.000 logologo
C1552406.00 ± 12.732Hymenoptera--0.500 logologo
C1562419.50 ± 0.711Nasonia vitripennis--0.000 logologo
C1572383.50 ± 0.711Nasonia vitripennis--0.000 logologo
C1582396.00 ± 0.001Ooceraea biroi--1.000 logologo
C1592402.00 ± 0.001Ooceraea biroi--1.000 logologo
C1602399.00 ± 0.001Ooceraea biroi--1.000 logologo
C1612394.00 ± 1.411Pogonomyrmex barbatus--1.000 logologo
C1622389.00 ± 8.491Tribolium castaneum--0.000 logologo
C1632385.00 ± 4.241Tribolium castaneum--0.000 logologo
C1642376.50 ± 0.711Tribolium castaneum--0.000 logologo
C1652390.00 ± 0.001Tribolium castaneum--0.000 logologo
C1661425.00 ± 0.001Anopheles gambiae--0.000 logologo
C1671378.00 ± 0.001Bombus terrestris--1.000 logologo
C1681314.00 ± 0.001Cloeon dipterum--0.000 logologo
C1691341.00 ± 0.001Cloeon dipterum--0.000 logologo
C1701316.00 ± 0.001Cloeon dipterum--0.000 logologo
C1711402.00 ± 0.001Camponotus floridanus--1.000 logologo
C1721384.00 ± 0.001Camponotus floridanus--1.000 logologo
C1731393.00 ± 0.001Camponotus floridanus--1.000 logologo
C1741367.00 ± 0.001Camponotus floridanus--1.000 logologo
C1751379.00 ± 0.001Camponotus floridanus--1.000 logologo
C1761392.00 ± 0.001Drosophila melanogaster--0.000 logologo
C1771404.00 ± 0.001Drosophila melanogaster--0.000 logologo
C1781387.00 ± 0.001Harpegnathos saltator--1.000 logologo
C1791388.00 ± 0.001Harpegnathos saltator--1.000 logologo
C1801386.00 ± 0.001Harpegnathos saltator--1.000 logologo
C1811385.00 ± 0.001Harpegnathos saltator--1.000 logologo
C1821377.00 ± 0.001Harpegnathos saltator--1.000 logologo
C1831399.00 ± 0.001Linepithema humile--1.000 logologo
C1841418.00 ± 0.001Manduca sexta--0.000 logologo
C1851381.00 ± 0.001Manduca sexta--0.000 logologo
C1861391.00 ± 0.001Manduca sexta--0.000 logologo
C1871417.00 ± 0.001Nasonia vitripennis--0.000 logologo
C1881381.00 ± 0.001Nasonia vitripennis--0.000 logologo
C1891414.00 ± 0.001Nasonia vitripennis--0.000 logologo
C1901395.00 ± 0.001Ooceraea biroi--1.000 logologo
C1911398.00 ± 0.001Ooceraea biroi--1.000 logologo
C1921395.00 ± 0.001Ooceraea biroi--1.000 logologo
C1931398.00 ± 0.001Ooceraea biroi--1.000 logologo
C1941399.00 ± 0.001Ooceraea biroi--1.000 logologo
C1951398.00 ± 0.001Ooceraea biroi--1.000 logologo
C1961398.00 ± 0.001Ooceraea biroi--1.000 logologo
C1971399.00 ± 0.001Pogonomyrmex barbatus--1.000 logologo
C1981401.00 ± 0.001Pogonomyrmex barbatus--1.000 logologo
C1991388.00 ± 0.001Tribolium castaneum--0.000 logologo
C2001370.00 ± 0.001Tribolium castaneum--0.000 logologo
C2011379.00 ± 0.001Tribolium castaneum--0.000 logologo
C2021373.00 ± 0.001Tribolium castaneum--0.000 logologo
C2031375.00 ± 0.001Tribolium castaneum--0.000 logologo
C2041376.00 ± 0.001Tribolium castaneum--0.000 logologo
C2051352.00 ± 0.001Tribolium castaneum--0.000 logologo


GENERAL INFORMATION

Who are we?
  • Computational Biology and Data Mining (JGU Mainz, Germany)
    • Dr. Miguel A. Andrade-Navarro; andrade@uni-mainz.de
    • Dr. Jean-Fred Fontaine; fontaine@uni-mainz.de
    • Dr. Pablo Mier; munoz@uni-mainz.de
  • Behavioural Ecology and Social Evolution (JGU Mainz, Germany)
    • Dr. Susanne Foitzik; foitzik@uni-mainz.de
    • Dr. Romain Libbrecht; rlibbrec@uni-Mainz.de
    • Marah Stoldt; mastoldt@uni-mainz.de
  • Developmental Neurobiology (JGU Mainz, Germany)
    • Dr. Carlotta Martelli; cmartell@uni-mainz.de

Sequence curator: Miguel A. Andrade Navarro (MAAN)

Repository developer: Pablo Mier

v1.0 release date: 12/2021



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