>CE|CSR-1_ce_
----------------------------------MQSDNVGRGRGSRGGS
RGGSGRGRGRGGYGDSYRPDLETRETHVTYQGK-----------------
-----------------------------VKYEGGDRHDFNYEKTPTGSY
RGSHRDGQEGSRGNRGSFRGGRGGYDRRRDDEESK------AENRFGGYN
RGANGGNYRGRTGGSGRGGSTQTTTVDPKYNGLILENSAEPKLKGLNSDM
NQKQNPRLALNIFGLEL--SERTIFRHVVQMKLIDRQHNKEYILTTMSAR
GRGNRAT---KQKDNFILLDILLKQW-AAKKGQQNLPAFAYDGAQSLFTL
EGIS------------LMVDIKKEDALEIPE-LSNFLKDSISFLSGDLEI
SCEPDLEKPSFVQTEL----NEWSDPRFYAYLDIVTSQ-SAIRSERY--L
SQSKGLY-------V--------HT------------------QSLEELR
VKWAVAAKGIHKGCRIVGA-NG-----PLPILELDPQSTQYY-ASIPLSQ
MLQYAFP-------------------------------------------
-------------------RDFPPNRIVNPNMKL----------------
----------------QRAVKLLLKDLKCNPYYDDKQIWATNTITVSDV-
-DYNAPKDPEF-------------------------RQKYP-NLKFPMLP
AVQCGTGPHK----------RLMPLEYLKVLPYQSIDRRVLEEFE----L
TPRANAPNERWSTLQKHYDQFGFN-----DQVMKDFGVQI-CNDPFNNVS
EIDGERVLAPSVAYADP-----------------VHVDDEKRDW----KA
QD---KKFVTPATIDHLMFVL---VAGYTRTWDAD-CDATKFVAKAFMQR
CKDKGMHI----GSYSM---DQHNGERGSENFLTSVFKNLVTHPNYRDSS
FTP--FVLFISDDVPNIHECLKFE-ERMSDIPTQHVLLKNVKKMRDNIEK
KSQGGRRAYDLTLDNIVMKANIKCGGLNYTA------------DIPRDLA
CWNEVSTFVIGMDVAHPDRNAAR-------EGNPSTVGLSCNSAENPYS-
--FIGDFLYTDPRREA----------IQDEILRKFTDQSVRNFAEIR--G
FPKKVIIFRDGVSFGEETAALK-EVEIIEQTIKTAAKSMGHSDY----AP
KVLAIVVKKRHHTRFYAKGGHHGNMPI----------------------N
PLPDTSVGGDIAEYGKRQIFIQAFRPVQGTAKVPSFLVIRDDEEVSDEH-
---VAKMVCAVCSLHQLVNSPTSIPTPVYVAHELAKRGTGLYK-------
---------------------------------AYRFKNG-ELFDDWETL
TTQLSYSTLDRLSKVRVV
>CE|SAGO-1_ce
--------------------------------------------------
---MSNITQVTSSMASASLSNKAPLPVG----------------------
--------------------------------------------------
-----------------------------------------HQPLAEKKP
KEV--------------------------------------NQEGT----
----PVQIVTNMRKINL-EKNHSIFKYSVQVLFVYQKSDGTELVLEKSKS
VGSGCDHERSKSHCLRVYRKAAKQCQ-ELKSG----GPFCYDSQGCLYSF
SKLKN-----------DEFSTNITGSDISNNPKFLRVEFKLAKVQESFQT
TTNDVAKSVNCRPAL--------QEKTILEAMNQIVST-APINHPNV--L
TIGNCVH-------YLYDDTNIDIRS-----------------ITGEGGK
SSAV----GASKSVRTLEGTGK----TPCLYMATELKTTLFHPDNCSLLK
VFMDYRG-------------------------------------------
--------------------FNGSLKANSPFVLK----------------
-------------------NKNAFIGLWCYTTHG-KCSDWKDDRPMIKIK
DFGLSAKETTF-----------ERDNK-KISVFNYFQVKYNMTLKYPDLF
TVVARGKDGKN---------QHIPVECLDLCNSQTVRTEQMVGTEQADLI
KLAAAKPHDRKKITDTVVNSIGLA--------SEPKGIIS-VGAPE----
SVTGLVLPKPDIYFSGG--------------KKVFWNDPKKRGPA-TDFM
PA---GTFIKP--TK--LTNW---EVVFDNGVQ------LVDCIQHLTST
MRQLGMEV----SNPTV----SLINRGYLRSIFENAKAANRQ--------
-----LIMFITKSMNNYHTEIKCL-EQEFDLLTQDIRFETAVKLA-----
-------QQQNTRKNIIYKTNMKLGGLNYEL----------------RSG
VFSNSKRLIIGFETSQRGGLGDA----------PIAIGFAANMMSHSQQ-
--FAGGYMFVKKSADN----------YGP-VIPEILLTILKQAKANRPND
RPDELLIYFSGVSEGQHALVNEYYANQVKAACGLF-----NESF----RP
HITLILASKVHNTRVYK----SENGGGVC--------------------N
VEPGTVIDHTIVSPVLSEWYHAGSLARQGTSKLVKYSLIFNTKKNEKLS-
--VYERLTNELCYEMQIVFHPTSLPIPLHIAGTYSERGSQMLA-------
---------------------------------LKKPIYT-NGEFNQVAT
NEQLGYASKKLFGTRFNA
>CE|SAGO-2_ce_
--------------------------------------------------
-----MEKQLKAMSVSDKPAAPAAQKLG----------------------
--------------------------------------------------
-----------------------------------------TAPLAAKKT
RN---------------------------------------EEWGT----
----KVNIDTNIRKLTI-KPNQPIYKYAVQVNYVFRKPDGTEATIEMSKS
AKKGTEHDNDKTRCQNVYNEAIKRYD-ELKTG----GPFFYDRQASLYTL
TKLKN-----------ESISFVVTDKICKRQ-NFKEAQFVLKKVDQSFQS
TSNDVIKTTNSCPAN--------ADKTLLEAMNIIVSG-PAFENKNV--I
TVGACVH-------Y--------LI---DP--TGVDVAYK---EYPEGQL
YSGV----GVSKSVKTLEG-TDKKVPSL--FMTTEMKTTLFHPDYAPLVE
LLQTFRG-------------------------------------------
--------------------FSTTLKANSPAAQR----------------
-------------------IEKAFVGLDVVLNYG-VHKGLGEDGVVMKIR
RFHTSAKETCF----EVEKS----TRE-FTNVFDYFKKKYGITLKYPDLF
TIEAKGKQGK----------IHFPAEVLLLCPNQTVTNDQMINNEQADMI
KMSAAQPHIRKTTTDTIVRNVGLA-------SNNIYGFIK-VEDPV----
NLEGMVLPKPKIAFAGN--------------RLADLANPK-SRFP-TDFN
RA---GQYYDA--KE--LTKW---ELVFVQNEE------VQGLAKQLADE
MVNNGMKC----SNPTM----SFIIRGDLEPIFKKAKAAGTQ--------
-----LLFFVVKSRYNYHQQIKAL-EQKYDVLTQEIRAETAEKVF-----
-------RQPQTRLNIINKTNMKLGGLNYAI----------------GSE
AFNKPNRLIVGFVTSQRVGGNPD---------YPISVGFAANMLKHHQK-
--FAGGYVYVHRDRDV----------FGS-IIKDTLLTIFKTCTEQR--G
RPDDILLYFNGVSEGQFSMINEEFSARVKEACMAF-QKEGTPPF----RP
HITIIASSKAHNERLYKSDK-----GRIV--------------------N
LEPGTVVDHTIVSNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEP
LWHLEQLTNDLCYDHQIVFHPVGLPVPLYIADRYSQRGAMVLA-------
--------------------------------ANQGPIYN-EGQIDLAAT
NSAYGYGEKKLFTTRFNA
>CE|PPW-1_ce_
--------------------------------------------------
-----MEKQLEAMFVSDRPAAPAAQKLG----------------------
--------------------------------------------------
-----------------------------------------TAPLAAKKT
RN---------------------------------------VERGT----
----KVNIDTNIRKLTI-KPNQPIYKYAVQVNYVFRKPDGTEATIEMSKS
AKKGTEHDNDKTRCQKVYNEAIKRYD-ELKTG----GPFFYDRQASLYTL
TKLKN-----------ESISFVVTDKICKRQ-NFKEAQFVLKKVDQSFQS
TSNDVIRTTNSCPAN--------ADKTLLEAMNIIVSG-PAFENKNV--I
TVGACVH-------YLID-----PT-----------VVDVAYKEYAEGQL
YSGV----GASKSVKTLEG-TDKKVPSL--FMTTEMKTTLFHPDYAPLVE
LLQTFRG-------------------------------------------
--------------------FSTTLKANSPAAQR----------------
-------------------IEKAFVGLDVVLNYG-VHKGLGEDGVVMKIR
RFHTSAKETCF----EVEKS----TRE-FTNVFDYFKKKYGITLKYPDLF
TIEAKGKQGK----------IHFPAEVLLLCPNQTVTNDQMINNEQADMI
KMSAAQPHIRKTTTDTIVRNVGLA-------SNNIYGFIK-VEDPV----
NLEGMVLPKPKIAFAGN--------------QLADLANPKSRFPT--DFN
RA---GQYYDA--KE--LTKW---ELVFVQNEE------VQGLAKQLADE
MVNNGMKC----SNPTM----SFIIRGDLEPIFKKAKAAGTQ--------
-----LLFFVVKSRYNYHQQIKAL-EQKYDVLTQEIRAETAEKVF-----
-------RQPQTRLNIINKTNMKLGGLNYAI----------------GSE
AFNKPNRLIVGFVTSQRVGGNPD---------YPISVGFAANMLKHHQK-
--FAGGYVYVHRDRDV----------FGS-IIKDTLLAIFKTCTEQR--G
RPDDILLYFNGVSEGQFSMINEEFSARVKEACMAF-QKEGTPPF----RP
HITIIASSKAHNERLYKSDK-----GRIV--------------------N
LEPGTVVDHTIVSNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEP
LWHLEQLTNDLCYDHQIVFHPVGLPVPLYIADRYSQRGAMVLA-------
--------------------------------ANQGPIYN-EGQIDLAAT
NSAYGYGEKKLFTTRFNA
>CE|WAGO-1_ce
---------------------------------------------MSPHP
PQPHPPMPPMPPVTAPPGAMTPMPPVPADAQKL-----------------
--------------------------------------------------
----------------------HQSTGNDACIKRLQQLNVEDGAKMYMKP
TEP--------------------------------------GKMGR----
----PVDIQTNVFGIEV-TKETTVHRFMVHAKADLTSTKE----VTFTKK
GKEDFVVQDRRDKCCNIFFLAVEKNP-EFFKMKDG-NQIVYDGQSTLYTT
VNLFSELDANGTKSKVFQINGADTGNDDLKT-LPCISLEIYAPRDNSITL
SSENLGKRTADQNIE-------VNNREYTQFLELALNQHCVRETNRFGCF
EHGKVYF-------L-------------NATEEGFDQRDC---VDVGDGK
QLYP----GLKKTIQFIEGPYGRGQNNP--SLVIDGMKAAFH-KEQTVIQ
KLFDITG-------------------------------------------
--------------------QDPSNGLNNMTREK----------------
-------------------AAAVIKGLDCYSTYT----NRKRHLRIEGI-
-FHESATKTRF----ELP------DGK-TCSIAEYYADKYKISLQYPNAN
LVVCKDRGNN----------NYFPAELMTVSRNQRVTIPQQTGNQSQKTT
KECAVLPDVRQRMIITGKNAVNIT---LENELLVALGIKV-YSEPL----
MVQARELDGKELVYQRS-------------------VMSDMGKW----RA
PP---GWFVKPATVP---DLWAAYAVGNPGCRFSI--GDVNQLVGMFIDS
CKKKGMVI-----KPPC-----ETGLYSTEKIMTQLEKVAAS-------K
CKY--VLMITDDAIVHLHKQYKAL-EQRTMMIVQDMKISKANAVVKD---
-------GKRLTLENIINKTNVKLGGLNYTV---------------SDAK
KSMTDEQLIIGVGVSAPPAGTKY-MMDNKGHLNPQIIGFASNAVANHE--
--FVGDFVLAPSGQDT----------MAS--IEDVLQNSIDLFEKNR-KA
LPKRIIIYRSGASEGSHASILAYEIPLARAIIHGY-----SK------EI
KLIFIVVTKEHSYRFFRDQLRSGGKATEM--------------------N
IPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDR-
---LEELTFTLCHHHQIVSLSTSIPTPLYVANEYAKRGRDLWG-------
-----------------------------ELTTKGPIEAKESQGERLKEL
TKEIGYKQTDLNQKRVNA
>CE|WAGO-5_ce
-------------------------------------------------M
NTGVVLLDQNDQKLYQTTANDACINRLKELNVE-----------------
--------------------------------------------------
-----------------------------------------SGAKIYTTP
TEP--------------------------------------GTLGK----
----QVDVGTNIFGVEV-TKETTVHRFVVHAKADLTSTKE----VTFTKK
GKEDFVVLDRREKCCNLFFNAVEKNP-DFFKMKDG-NHIVYDGQSTLYTT
INLFSELDCNQTKSKVFQINGADTGNDELKT-LPCISLEIHAPRDNSITI
SAKILGERTADQNIE-------VNNREYTQFLELALNQHCTRETKRFGCF
EHGKVYF-------L-------------NATEEGFDQRDC---VDVGDGK
ALYP----GLKKTIQFIEGPFGRGQNNP--SLVIDGMKAAFH-KEQTVIQ
KLFEITG-------------------------------------------
--------------------QDPSNGLSSMAREK----------------
-------------------ATPVIKGLDCYSMYT----SRKRHLRIVGI-
-FHESATGTRF----ELP------DGK-TCSIAEYFRDKYSINLQYPKAN
LVVCKDRGNN----------NYFPAELMTISKNQRATIPQQTQSQKT--T
KECAVLPDVRQRIIIKGKTAVNIT---AENELLNALGIKV-YSEPL----
-----KVSLKELGYQRS------------------TVKSELGKW----RP
PP---GSFVKPAAFQ---DLWALYAVGNQNSRFSV--SDLSQFTGMFIDA
CKKRGMII----KPPSE---TSLCHMDNIISLLENAAASKCK--------
--F--AFVITDDSITHLHKKYKAL-EQKSMMVIQDMKISKANSVVKD---
-------GKRLTLENVINKTNMKLGGLNYTV---------------SDAK
KSMTDEQLIIGVGVSAPPAGTKY-MMDNKGHLNPQIIGFASNAVANHE--
--FVGDFVLAPSGQDT----------MAS--IEDVLKSSIDLFEMNR-NT
LPKRIIIYRSGASDGSHASILAYEIPLARATIQGY-----SK------DI
NLIYIIVTKEHSYRFFRDQLRSGGKATEM--------------------N
IPPGIVLDSAVTNPACKQFFLNGHTTLQGTAKTPLYTILADDCNAPMDR-
---LEELTYTLCHHHQIVALSTSIPTPLYVANEYAKRGRDLWA-------
------------------------------HGPNEANEYH---EEHLKEL
SKQLGYKNTVFNKTRINA
>CE|PPW-2_ce
-------------------------------------------MPATPVP
PVTMPPVPPVGFPPVTAPPGLHPPPPVPPVPVP-----------------
--------------------------------------------------
----------------TLPVTSEHKTAHDACIKRLEQLEIPPDPKIYPSP
TEP--------------------------------------GTFGS----
----VTEVLTNVFGVEV-HKTSNFYQYSVHITAELSSKKE----VTFTKK
GKEDFIVHDRHEKCSAILFHALNRFE-DFFKSSE--NCIIYDGQSILFTS
MNLFEGIPTGKIKTKVFQINGADTNLKDLMV-LPCIKLEVFPTKNPVVNF
SLEDIGRRTSDSNIE-------SVNMAYKQILDLAMSQYAIRETSKCVVF
EHGKMFF-------I-------------NPLQEGYAPCDI---VEVGDGK
QMKP----GLKKTLQFIEGPYGRNQNNP--SIVIDGMKVAFH-MEQLVFQ
KLSSITS-------------------------------------------
---------------------NLANGITGSERER----------------
-------------------CAAVIKGLDCHSNYR----GRTRHHKIESI-
-HHEGAATARF----ELE------GGG-TCTVATYFKDKYKIQLRYPNAN
LIVCKERGAL----------NFYPMELITISPNQRVRITQQTSSQSQRTT
KESAVLPDIRQRLIMTGKIAAKIT---AENEVLGKMGVTV-CDEPL----
VVKGRNLPAIRLASFET---------------GEHLINPRDCKW------
RP---QRYNRSAVAP---KVWA--LYGVGSPGSQMNRDVMRRFCDEFMNM
SRSKGILF----PPPGD---VNLLTPDAIENRLREAANAGCT--------
--F--VLCITEDNITCLHQKYKFI-EHHTQMIVQDMKLSKALSVVNA---
-------SKKLTLENVINKTNVKLGGSNYVY----------------LDT
KNFLQEHLIIGVGISSPPPGTKY-IMESRGILNPTIVGFAYNGNGKQE--
--FSGDFVLNAAGQET----------IAP--IEDIVSYSIKGYKKFHDGK
APKRITIYRSGSSEGNHGPIISYEVPLARVAMRNF-----SP------DT
QLLYIVVSKEHTYRFFKKESGGSSSGGSNSAGASNSGTLTSAPPKPWELN
IGPGLTVDYGVTNPACKQFFLNSHMTLQGSAKTPLYTVLADDRNIGMSA-
---LEEFTFNLCHLHQIVGLPTSIPTPLYVANEYAKRGRNLWN-------
---------------------------EAINANEIPEVTGPESARLKKMT
DGISYMGSGDMIDRRVNA
>CE|WAGO-4_ce
------------------------------------------------MP
ALPPVYTPSGAPSSVHAPPAVPPVPVPTQPLRS-----------------
--------------------------------------------------
----------------------EYQTSNDACIKRLEELNIAPAAKLYPTP
TEP--------------------------------------GKCGV----
----EAEIQTNVFGIEM-HQDSLFYQYSVNITTELKNGKE----VTFTKK
GKDDFVVTERHDKCCAILFRALGDYE-EFFKTSD--SCLIYDGQSILFSN
VDLFQGFREGAVKTKYMQLDGGEMDHKDLKS-LPCIKLEVFPTKNPAVKF
TREAVARRATDSNLD-------SVSLAYQQILELALTQPCLRNTARYVVF
DHGKMFF-------I-------------DPLGEGFEKCDV---VDVGDGK
QVVP----GLKKTINFIEGPYGRGRSNP--SVVIDGMKVAFH-KNQPILD
KLKEITT-------------------------------------------
--------------------QPVEHGLKGLEKDR----------------
-------------------CAAVIKGLDCYSTYG----GRERHHKIEGI-
-HHEGARNARF----ELN------DGG-SCTVAQYFEDVYNITLRYPDTN
LIVSKERGNI----------NFYPMELLKISSHQRVQIPQLTSAQSQKTT
KESAVLPDVRQRLILTGKNAAQIS---SDNEVLGKMGVSV-CEDPL----
MVKGRSIPAVKLANAEI---------------GANPINVKDNKW------
RA---NRFTRPATAP---NVWAMYVVGTASTRITL--DTLKKFADEFAAM
CKSKGVNM----PAPAD---ISLIHMDAIESRLYDATKANCT--------
--F--VFIITDDSITTLHQRYKMI-EKDTKMIVQDMKLSKALSVINA---
-------GKRLTLENVINKTNVKLGGSNYVF----------------VDA
KKQLDSHLIIGVGISAPPAGTKY-AMENKGVLNPNVIGYAYNAQHNQE--
--FSGDFVLNSASQDT----------LAP--IEDIVMHSLNEYQKFHDGG
LPRRVIVYRTGTSEGNHGSIMAYEIPLARAAMRDF-----SP------DI
QLVYIVVSKDHSFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLN
IAPGILVDSIVTNPACKQFFLNSHITLQGTAKTPLYTVLADDAKVSMTA-
---LEDITYKLCHLHQIVGLPTSLPTPLYVANEYAKRGRNLWNEAVALNN
VPT---------------------------------VSGP-EADRLKELT
KSICYKASGDLTGRRVNA
>CE|NRDE-3_ce
----------------------------MDLLDKVMGEMGSKPGSTAKKP
ATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTP-----------------
--------------------------------------------------
----------------GSQQGSLGGRIPKREHTDR------TGPDPKRKP
L----------------------------------------GGLSVPDSF
NNFGTFRVQMNAWNLDISKMDERISRIMFRATLVHTDGRRFELSLGVSAF
SGDVNRQQR-RQAQCLLFRAWFKRNP-ELFKGMTDPAIAAYDAAETIYVG
CSFFDVEL--------TEHVCHLTEADFSPQ-EWKIVSLISRRSGSTFEI
RIKTNPPIYTRGPNAL----TLENRSELTRIIEAITDQ--CLHNEKF--L
LYSSGTF----------------PT----------KGGDI---ASPDEVT
LIKS----GFVKTTKIVDR-DG----VPDAIMTVDTTKSPFY-KDTSLLK
FFTAKMD---------QLT---NSGGGPRGHNGGRERRDGGGNSRKYDDR
RSPRDGEIDYDERTVSHYQRQFQDERISDGMLNT----------------
-------------------LKQSLKGLDCQPIHL-KDSKANRSIMIDEI-
-HTGTADSVTF----EQKLPDG--EMK-LTSITEYYLQRYNYRLKFPHLP
LVTSKRAKCY----------DFYPMELMSILPGQRIKQSHMTVDIQSYMT
GKMSSLPDQHIKQSKLVLTEYLKLGDQPANRQMDAFRVSLKSIQPI----
VTNAHWLSPPDMKFANN---------------QLYSLNPTRGVR----FQ
TN---GKFVMPARVK------SVTIINYDKEFN----RNVDMFAEGLAKH
CSEQGMKF----DSRPNSWKKVNLGSSDRRGTKVEIEEAIRN-------G
VTI--VFGIIAEKRPDMHDILKYF-EEKLGQQTIQISSETADKFMRDH--
-------GGKQTIDNVIRKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMR
AKLYAKTQFIGFEMSHTGARTRFDIQKVMFDGDPTVVGVAYSLKHSAQ--
--LGGFSYFQESRLHK----------LTN--LQEKMQICLNAYEQSS-SY
LPETVVVYRVGSGEGDYPQIVN-EVNEMKLAARKK-----KHGY----NP
KFLVICTQRNSHIRVFPEHINERGKSMEQ--------------------N
VKSGTCVDVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNE-
---IMNVTYHLAFAHQVSYAPPAIPNVSYAAQNLAKRGHNNYKTHTKLVD
MNDY------------------SYRIKEKHEEIISSEEVD-DILMRDFIE
TVSNDLNAMTINGRNFWA
>CE|WAGO-11_ce
----------------------------------------MSNQEPYRIP
KRTASDPNQSGSQGSCVRPNQEGNVKKEESVNS-----------------
--------------------------------------------------
-----------------------------------------APRRMFTLP
SSSSTSGAQVF------------------------------NPIG-----
----KCQVQTNSFKIDITKMPKRLLRLSMETRLCGGKTEL----------
---------------------------NLNDG-------VQAVAGNLNSQ
EDFTTQ--------------------------EWSQISNYLRKKNAEFKV
KISPNGFVYTNGPNS----LSDANRQELPRLVEIATSE--VLNTPEY--L
QFGNQTY-----------------------------AVNEPAVSSPDALS
EIRS----GFDKSVRLVDGENG----STEIIMTIDNKLAPFH-KSTSVLK
MICDKFE---EIVNPARQHRGSQDRRGDRDRGYRGGRSYGHDNRRRSRSR
SPQDRGDRGDRGNHHRDHNEDWDERKVKEVERRL----------------
----------LEEPRALGSIADALKGLIVESVHL----------------
-SKDVNRNSRI------KLNEGKNDEQ-EISVADYYLKQYNYKLKFPYLP
MIVSKRFRSE----------TMFPVELLKIVPGQKISIQKINPNVQSAMT
GPNSILPSKHVRIVARILESSLKI---ASNPYLKTFGIRI-SKDPI----
KLEAKILSPAQLSFNKY----------------SIMPKPGSVQFE---PS
RE---DKFFKP------AKIYEVAVIAFRVVSI-----NLSDFCMKLCDL
CRRSGLEIRRETRDWIKIENFNPTSTIELKEQMKRLQQSNCS--------
--I--IIGITEEKKPEVHDVLKYF-EAAVGLQTMQIHSKTAGFIIS----
-------GNGQTAGNVIKKLNLKCGGINYIVEVPQSFNRTVVCSNNSFVQ
KKLFDGTQFIGFEMTHGAARTLFDKSNGTFDGEPTIVGCAYSLQKATD--
--LGGFNWFQEQNEYR----------LKN--LGTHIPKCLQYYKESS-GS
LPEKIVIYRTGAGEGDFDRVQQ-EITEIRSSFAEV-----QEGY----KP
SLVVIVANKTSHLRVFPVEIREGDTAMKQ--------------------N
VRSGTCLDGKITSAGREEFVLISQTALISTAKPTKYTIAANDPKWSKNE-
---VMNLTYILSFAHQVCYQPPAVPHILYAADNLAKRGRNNFIQHKKLGE
LSK-------------------TIQATLTKYSDLNIEMDS-KELSGELVE
DITKSMNVMAIKARNFWA
>CE|HRDE-1_ce
-----------------------------------------------MAD
LLDKIMGSSSSNRIPKRDNRMNQDKDEPTSK-------------------
--------------------------------------------------
-----------------------------------------RSAPMFSTP
KST--------------------------------------TPIGR-DSF
ATMDTMNVQMNMFPVDIKDMPHKIQRFQVDVIVCSSNGKQINANLGVLAA
KGDVNSHN--RRLAQYYIMRTVHDKL-LVKFSGKSHHFLAYDCAATLYLP
EGVYTGD---------DQEEVTLTIDDFPKE-EWKFVSKLSRRKDDSYLV
VLKPAGFVYTQGEVAQ----EEANRMELTRIIEIVTSQ--KLNNEDY--L
QFGNATF-------P--------RL---SP--------PH---SEPDAIS
EIRS----GFAKVSRLSQN-GGGKA-----FMTVDTKISPFY-KDTSVIK
FSSNKLS----------------EMKGGGGGRGGYGRSDSRDSRGGYRGG
RSDSRDFRGVYGNRGGNDRYRDESRGRRDMYDSRRDSGSSNGADYSPSDA
AELEHAFGERGNTKRC---IEEALKGLDVECTHL-----KGNLIRVSSI-
-AENNAENTSF----MMKDDKG--ERE--VTVAEYFLLQYNIKLKYPRLP
LVVSKRFKHE----------SFFPMELLRIAPGQRIKVNKMSPTVQSAMT
GRNASMPQHHVKLVQDILRDNLKL---EQNKYMDAFGIKLMSTEPI----
QMTAKLLPPAQIKFKGQ------------------TYMPDMSRPA---FR
TQ---DKFVEP--AR--IRKIG--IVVFDNCIQMR---QAEDFCDKLSNF
CRDNGITVEKDSRDWSI-RELNSSDSVAIQNLMKKWLDDRVD--------
--I--LVGIAREKKPDVHDILKYF-EESIGLQTIQLCQQTVDKMMGGQ--
-------GGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNNETLR
KKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNSTQ--
--LGGFTYLQTQKEYK----------LQK--LDEFFPKCVRSYKEHS-KT
LPTRIVIYRVGAGEGNFNRVKE-EVEEMRRTFDKI-----QPGY----RP
HLVVIIAQRASHARVFPSCI-SGNRATDQ--------------------N
IPSGTCVENVLTSYGYDEFILSSQTPLIGTVRPCKYTILVNDAKWSKNE-
---LMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKRGRNNYKIHQRYVN
LQA-------------------VENRIIKDHSELINEDMR-EELAAAIVD
EMSVAMNGMTIPKRNFWA
>CE|WAGO-10_ce
-----------------------------------MPTTVQNPSPTGFLP
QIPFRIPKRTRRSSEVDVPATKRPAPPLTSSTS-----------------
--------------------------------------------------
------------------------------------------------LP
TRDSFSIIE-----------------------------------------
----TRDVQLNMFALNISGMPRKIQRFHVDTLIKGKNGKIFNVNHGVLAN
SGDINSHN--KRLAQHALMQKFHKKRRELFGQHDY-HILAYDCANTLYLP
DGVYLGR---------NEEECTFKSDDFSPE-QWNITSKLSRKKDYTYVM
KIRPSGFIYTSGEEA----SEVANRMELTRCVEIVTSQ--KLNNSDY--C
QFGNDTF-------SFRAQ----PV------------------SEPDATS
EIRS----GFAKVSRIVEGRNGKNEM----LMAIDTKASPFY-KSTSVLN
FVCGKYL------------------------------EKRGSSRNDYRGR
GDYNRKKTGGGSTDAPDHQDVAEVERSLEYRENR----------------
-----------------QQIEEALKGLLVSAAHL---KNSTNLIMISRV-
-AETNSETTKF----------MTNNGEREISVADHYLEAYNYRLKYPKMP
LVVSKRFRDE----------CFYPMELLQVAPGQRIKDHKMSAAVQMAMK
GQKSTLPQKHVDLVKHVLSRNLKL---DRNLYMDAFGIKLESAELV----
KLQSKILPPPQIKFKDE------------------VYMPKMGNPV---FR
TN---GRFVDPADIN------AVAIVVFDRAIDMR---QAENFCDRLSCY
CRENGITVKKSSRDWPI-REINSEDSVAIKNAMEKWFSKGVN--------
--I--LVAIAKEKKPDVHDVLKYY-EASVGLQTIQVCKQTVDMMLSS---
-------GGRQTADNVMRKFNLKCGGTNFFVQIPRSVNGRTVCADAHLLN
EKLFERVQFIGFDISHGASRTLFDRSTGKMDGEVSIVGVSYSLSHSTH--
--LGGFAYMQTQKEYK----------LQK--LDEVFPKCVDSYRNHT-GR
LPSKIVIYRIGAGEGDFKRVKE-EVDKIRGTFNRI-----QPDY----RP
QLVVIIAQRDSHVRVFPAHI-TGSKAGQQ--------------------N
VTSGTCVDSVITSLGHQEFILSSQMPLLGTVRPCKYTILTNDPNWTKTE-
---ITHLTYFRAFGHQVSYQPPSFPDVLYAAENLAKRGRNNYKVHQRFVN
LQA-------------------VERSVIAENSDLVSEEMR-EQLAAAIVD
EMSAAINGMTISKRNFWA
>CE|C04F12.1_ce
-----------------------------------MPSKKNKKAAAAERS
ATLSASASQQVAKDEQSAPVVPTPELSRVSVSS-----------------
--------------------------------------------------
---------------NPPTPSAIEKPVPLPVPS--------KPLFEYEPP
AQLEALAK------------------------------------NK----
----PVKVTTNSYELEL--KPTPVFRYDVSVLKSFDDSTRDPIELAGSKG
----------GDRQRQADLTEIVKVA-LTLEGLGN-LNIFYDGAAMLFTT
QKFETKTE--------KQQAIFMPIPSDHPKLSTSLKESQFGRASGKFHV
SIELNSKQSELNTIDLLNERLDSAACPVTQMAQIALSAEAKQNGFII--L
DGGHELF-------DQKNT----RR------------------TIGKDGV
EDMD----GVAASIK-MAQ-GNKKTGSA--HLVMDYKKKQFF-KTGPLKD
LIKGINP-------------------------------------------
--------------------------------NQ----------------
-------------------LRSYLKGLRVHTTYS------HQSIFIDGI-
-SNVPIGEIKLPDGTPLLDDCARVSGK-PKSFFD------------ASKP
AVQVNQYNKREGRRMV----YSFPIENLLVKPNQKLTQNHGEP-------
-PRSIKPELRFDLIRKVGESAKLL---SPNQTLKSIGIAI-NPEPI----
VVEAMTVPKPTILYKDG--------------AFTSPDLLNRTSWDVQARN
HQSLKGGFVEPMKINKILILYNSQSYSQASPKE-----AVVELQSILSKK
AKDVGMTI----GQIDVEDLNDPDIIGAIENKMTILKTSQVK--------
--P--IVIYADHTSEGTHSTLKLQ-ERLCEVITQQVALDKSLKRT-----
-------PGKVTANNLLMKLNLKYGGVNHKV----------RVDNSISHL
WGDTSNTLIISYDVCHSSGKVYK---KDEICDEPSCVGFGFNGTACPEA-
--FIGDFHYQLPRHEQ----------VDEHLLKLRARFMLNHYITSR-KK
YPQQVVILRDGVSEGQHKMVRNEEFQAIKQSIMNVFNEKKAK------AP
SFALLVVTKRHANRLLIKDQ-----NGYT--------------------N
VPPLTAIDQTIVKKQGNEVIFVSHCPLNGTAQPIVINTLVNDGIFKTND-
--QLVQFITALCCAHQKSTNIVSLPESIYAADEYAKRGADLFQ-------
-----------------------SYKLKHRDLPTTTIDDS-TQLDYEKIT
LILCFQTSSFKNKRIA--
>PIWI|PRG-1_ce
--------------------------------------------------
-----MASGSGRGRGRGSGSNNSGGKDQKYLGT-----------------
--------------------------------------------------
-----------------------------------------IQPDLFIRQ
QGQSKT-----------------------------------GSSGQ----
----PQKCFANFIPIEMTQSDYSIYQYHVEF-EPTVDSKA----------
-----------------NREKMLRDN-NVTDEIG--HHFVFDG-MILYLK
EEW-----------------------------EQNQMIEVQHPIDRSLIC
IRFKQTNRFLVDDPQ------------TINIFNTIIRR--SFDALQL--T
QLGRNYF-------NWGD-----SR------------------AVPDYNM
SILP----GYETAIRMYEE-NF--------MLCVENRFKMV--REESMYI
LFHKELR-------------------------------------------
----------------------SCQNNPQRVQEK----------------
-------------------MNEMYGGTTIITRYN------NKLHRYTRL-
-DYSISPLSEF-----------VKDGQ-SITLKEYFKNQYGIEITVDDQP
IIISEGKPKQPGEPPQV---SYIVPELCF--PTGLTDEMRKDFKMMKEIA
KHTRMSPQQRLVESRKLIVDLSKN--EKVMECFKYWGISL-GQDLA----
NVQARVLKSEPLQGKKT-------------------YEGKQAEWA--RGV
KE---CGIYRG--SN--MTNW---IVIGPGSGNSG--LLSQKFIEEARRL
GKILQVQL----GEPMC----VPIRGISPNDYLEGVKGAIKQ---VDGED
IHM--LVVMLADDNKTRYDSLKKFLCVECPIPNQCVNLRTLAGKSKDGGE
NK-----NLGSIVLKIVLQMICKTGGALWKV-------------------
NIPLKNTMIVGYDLYHDSTLKGK-----------TVGACVSTTSNDFTQ-
--FYSQTRPHENPTQL----------GNN--LTHFVRKALKQYYDSNDQT
LPSRLILYRDGAGDGQIPYIKNTEVKLVRDACDAVTDKAAELSNKVQEKI
KLAFIIVTKRVNMRILKQGS---SLDNAI--------------------N
PQPGTVVDTTVTRPERMDFYLVPQFVNQGTVTPVSYNIIHDDTDLGPDK-
---HQQLAFKLCHLYYNWQGTVRVPAPCQYAHKLAFLTAQSLH-------
--------------------------------------------------
----DDANGCLRDKLFFL
>PIWI|sp|Q9VKM1|PIWI_DROME
------------------------------MADDQGRGRRRPLNEDDSST
SRGSGDGPRVKVFRGSSSGDPRADPRIEASRER-----------------
--------------------------------------------------
-------------RALEEAPRREGGPTERKPWGD-------QYDYLNTRP
AELVSKK----------------------------------GTDGV----
----PVMLQTNFFRLKT-KPEWRIVHYHVEF-EPSIENPR----------
----------------VRMGVLSNHA-NLLG-----SGYLFDG-LQLFTT
RKFE----------------------------QEITVLSGKSKLDIEYKI
SIKFVGFISCAEPR-------------FLQVLNLILRR--SMKGLNL--E
LVGRNLF-------D--------PR---------------AKIEIREFKM
ELWP----GYETSIRQHEK-DI--------LLGTEITHKVM--RTETIYD
IMRRCSH-------------------------------------------
--------------------------NPARHQDE----------------
-------------------VRVNVLDLIVLTDYN------NRTYRINDV-
-DFGQTPKSTF-----------SCKGR-DISFVEYYLTKYNIRIRDHNQP
LLISKNRDKALKTNASEL--VVLIPELCRV--TGLNAEMRSNFQLMRAMS
SYTRMNPKQRTDRLRAFNHRLQNT--PESVKVLRDWNMEL-DKNVT----
EVQGRIIGQQNIVFHNG-----------------KVPAGENADWQ--RHF
RD---QRMLTTPSDG--LDRW----AVIAPQRNSH---ELRTLLDSLYRA
ASGMGLRI----RSPQE----FIIYDDRTGTYVRAMDDCVRS-------D
PKL--ILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNR------
-------SLMSIATKIAIQLNCKLGYTPWMI-------------------
ELPLSGLMTIGFDIAKSTRDRKR-----------AYGALIASMDLQQNS-
--TYFSTVTECSAFDV----------LAN-TLWPMIAKALRQYQHEH-RK
LPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTE-----YARV-QLSPP
QLAYIVVTRSMNTRFFLNGQ-----------------------------N
PPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEK-
---MQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLH-------
--------------------------------------------------
----SIPQNALEKKFYYL
>PIWI|sp|O76922|AUB_DROME
-----------------------------------------MNLPPNPVI
ARGRGRGRKPNNVEANRGFAPSLGQKSDPSHSE-----------------
--------------------------------------------------
-------GNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKSEGDPRGSVRG
RRLITDLVYSRPPGMTSKK----------------------GVVGT----
----HITVQANYFKV-LKRPNWTIYQYRVDF-TPDVEATR----------
----------------LRRSFLYEHK-GILGG------YIFDG-TNMFCI
NQFKA-----------VQDS------------PYVLELVTKSRAGENIEI
KIKAVGSVQSTDAEQ-------------FQVLNLILRR--AMEGLDL--K
LVSRYYY-------D--------PQ---------------AKINLENFRM
QLWP----GYQTSIRQHEN-DI--------LLCSEICHKVM--RTETLYN
ILSDAIR-------------------------------------------
--------------------------DSDDYQST----------------
-------------------FKRAVMGMVILTDYN------NKTYRIDDV-
-DFQSTPLCKF------KTNDG------EISYVDYYKKRYNIIIRDLKQP
LVMSRPTDKNIRGGNDQA--IMIIPELARA--TGMTDAMRADFRTLRAMS
EHTRLNPDRRIERLRMFNKRLKSC--KQSVETLKSWNIEL-DSALV----
EIPARVLPPEKILFGNQ----------------KIFVCDARADWT--NEF
RT---CSMFKN--VH--INRW----YVITPSRNLR---ETQEFVQMCIRT
ASSMKMNI----CNPIY----EEIPDDRNGTYSQAIDNAAAN-------D
PQI--VMVVMRSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPT-
-------GLMSIATKVVIQMNAKLMGAPWQV-------------------
VIPLHGLMTVGFDVCHSPKNKNK-----------SYGAFVATMDQKESFR
--YFSTVNEHIKGQEL----------SEQ--MSVNMACALRSYQEQH-RS
LPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEI-----YKSAGKQEGC
RMTFIIVSKRINSRYFTGHR-----------------------------N
PVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADK-
---LQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAESIN-------
--------------------------------------------------
----RAPSAGLQNQLYFL
>PIWI|sp|Q7PLK0|AGO3_DROME
----------------------------------MSGRGNLLSLFNKNAG
NMGKSISSKDHEIDSGLDFNNSESSGERLLSSH-----------------
-------------------------------------------------N
IETDLITTLQHVNISVGRGRARLIDTLKTDDHTSNQFITSESKENITKKT
KGPESEAIASENGLFFPDLIY--------------------GSKGS----
----SVNIYCNYLKL-TTDESKGVFNYEVRF-FPPIDSVH----------
----------------LRIKYLNDHK-DKLGG-----TKTFDG-NTLYLP
ILLPN-----------KMTVFISKAE------DVELQIRILYKKKEEMRN
---------------------------CTQLYNILFDR--VMKVLNY--V
KFDRKQF-------D--------PS---RP------------KIIPLAKL
EVWP----GYVTAVD-EYK-GG-----L--MLCCDVSHRIL--CQKTVLE
MLVDLYQ-------------------------------------------
-------------------------QNVEHYQES----------------
-------------------ARKMLVGNIVLTRYN------NRTYKINDI-
-CFDQNPTCQF----EIK------TGC--TSYVEYYKQYHNINIKDVNQP
LIYSIKKSRGIPAERENLQFCLIP-ELCYL--TGLRDEVRSDNKLMREIA
TFTRVSPNQRQMALNKFYENVSNT--PAAQEILNSWGLSL-TNNSN----
KISGRQMDIEQIYFSKI-----------------SVSAGRSAEFS--KHA
VT---NEMLKV--VH--LSKW---IIIHLRNYR----QAATSLLDNMKQA
CESLGMNI----SNPTM----ISLDHDRIDAYIQALRRNITM-------N
TQM--VVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDL-----
-------KIRSVVQKIVLQMNCKLGGSLWTV-------------------
KIPFKNVMICGIDSYHDPSNRGN-----------SVAAFVASINSSYSQ-
--WYSKAVVQTKREEI----------VNG--LSASFEIALKMYRKRN-GK
LPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVCGN--------------RI
KISYIVVQKRINTRIFSGSG-----IHLE--------------------N
PLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDI-
---IQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAYLIGQSIQ-------
--------------------------------------------------
----RDVAEALSEKLFYL
>PIWI|sp|Q8TC59|PIWL2_HUMAN
------------MDPFRPSFRGQSPIHPSQCQAVRMPGCWPQASKPLDPA
LGRGAPAGRGHVFGKPEEPSTQRGPAQRESVGLVSMFRGLGIETVSKTPL
KREMLPSGRGILGRGLSANLVRKDREELSPTFWDPKVLAAGDSKMAETSV
GWSRTLGRGSSDASLLPLGRAAGGISREVDKPPCTFSTPSRGPPQLSSPP
ALPQSPLHSPDRPLVLTVEHKEKELIVKQ------------GSKGT----
----PQSLGLNLVKIQC--HNEAVYQYHVTF-SPNVE-------------
-------------CKSMRFGMLKDHQ-AVTG-----NVTAFDG-SILYLP
VKL-----------------------------QQVLELKSQRKTDSAEIS
IKIQMTKILEPCSDL------------CIPFYNVVFRR--VMKLLDM--K
LVGRNFY-------D--------PT---------------SAMVLQQHRL
QIWP----GYAASIRRTDG-GL--------FLLADVSHKVI--RNDCVLD
VMHAIYQ-------------------------------------------
-------------------------QNKEHFQDE----------------
-------------------CTKLLVGNIVITRYN------NRTYRIDDV-
-DWNKTPKDSF----TMS------DGK-EITFLEYYSKNYGITVKEEDQP
LLIHRPSERQDNHGMLLKGEILLLPELSFM--TGIPEKMKKDFRAMKDLA
QQINLSPKQHHSALECLLQRIAKN--EAATNELMRWGLRL-QKDVH----
KIEGRVLPMERINLKNT-----------------SFITSQELNWVKEVTR
DP---SILTIP------MHFW---ALFYPKRAM----DQARELVNMLEKI
AGPIGMRM----SPPAW----VELKDDRIETYVRTIQSTLGA-----EGK
IQM--VVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPT-----
-------RLRSVAQKILLQINCKLGGELWGV-------------------
DIPLKQLMVIGMDVYHDPSRGMR-----------SVVGFVASINLTLTK-
--WYSRVVFQMPHQEI----------VDS--LKLCLVGSLKKFYEVN-HC
LPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAF------ENY----QP
KMVVFVVQKKISTNLYLAAP-----QNFV--------------------T
PTPGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDH-
---MQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHILH-------
--------------------------------------------------
----HEPAIQLCENLFFL
>PIWI|sp|Q7Z3Z4|PIWL4_HUMAN
----------------------------------MSGRARVKARGIARSP
SATEVGRIQASPLPRSVDLSNNEASSSNGFLGT-----------------
--------------------------------------------------
-------SRISTNDKYGISSGDAGSTFMERGVKNKQ-----DFMDLSICT
REKLAHVRNCKT-----------------------------GSSGI----
----PVKLVTNLFNLDF-PQDWQLYQYHVTY-IPDLASRR----------
----------------LRIALLYSHS-ELSN-----KAKAFDG-AILFLS
QKL-----------------------------EEKVTELSSETQRGETIK
MTITLKRELPSSSPV------------CIQVFNIIFRK--ILKKLSM--Y
QIGRNFY-------N--------PS---EPM------------EIPQHKL
SLWP----GFAISVSYFER-KL--------LFSADVSYKVL--RNETVLE
FMTALCQ-------------------------------------------
------------------------RTGLSCFTQT----------------
-------------------CEKQLIGLIVLTRYN------NRTYSIDDI-
-DWSVKPTHTF----------QKRDGT-EITYVDYYKQQYDITVSDLNQP
MLVSLLKKKRNDNSEAQL--AHLIPELCFL--TGLTDQATSDFQLMKAVA
EKTRLSPSGRQQRLARLVDNIQRN--TNARFELETWGLHF-GSQI-----
SLTGRIVPSEKILMQDH-----------------ICQPVSAADWS--KDI
RT---CKILNA--QS--LNTWL--ILCSDRTEYVA-----ESFLNCLRRV
AGSMGFNV----DYPKI-----IKVQENPAAFVRAIQQYVDP-------D
VQL--VMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNKQG-----
-------MMMSIATKIAMQMTCKLGGELWAV-------------------
EIPLKSLMVVGIDVCKDALSKDV-----------MVVGCVASVNPRITR-
--WFSRCILQRTMTDV----------ADC--LKVFMTGALNKWYKYN-HD
LPARIIVYRAGVGDGQLKTLIEYEVPQLLSSVAES-----SSNT----SS
RLSVIVVRKKCMPRFFTEMN-----RTVQ--------------------N
PPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDH-
---MQRLTFKLCHLYYNWPGIVSVPAPCQYAHKLTFLVAQSIH-------
--------------------------------------------------
----KEPSLELANHLFYL
>PIWI|tr|A7SQI3|A7SQI3_NEMVE
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
-----IPLSCNYIRIHC--PEQAVFQYCVSY-SPEIDNRS----------
----------------ERFHLLQQHP-GFRG-----PQKAFDS-TMLFLP
RRLP----------------------------QPVTQLQSTRRSDGSPVT
VTITFTRVVPPDDA-------------IFQVYNILFRR--VMKILDM--Q
QVGRYFY-------N--------PK---TPA------------HIPQHNL
VLWP----GYITSLQHYEG-GL--------MLLCDVHHRLL--RTDSCLD
YMLNMHS-------------------------------------------
-------------------------KVGDRFRDE----------------
-------------------VSKELIGSVVLTTYN------NKTYRVDDID
WNKRPTSTFTF------------HNGE-QMTFVEYYKKSYEIEIRDLDQP
MIVNRPKKTEQKRGGVIEV-ILLIPELCKL--TGLNDAMRKDFRVMKDIA
AHTRVNPMQRQEAMKKFVMSINST--PEALEQLTAWNLRL-DTSTL----
MTEGRQFPPEKIIYGNT-----------------TGSAGDQADWG--RDA
TR---EKVISA--VN--LNNW---MVFFTQRDSGK----ANDFVQTMNKC
APAMGIQV----NQPKM----NQLRDDRTETYLRSIRENLHP-------Q
VQV--VVVIFPTSRDDRYAAVKKLCCVESPVPSQVIISKTISNPT-----
-------KLRSVVQKIALQINVKLGGELWAL-------------------
DIPSRSLMVCGIDVYHDKARGGR-----------SVGGLVCSMNRSLTR-
--WYSDVCFQSPGQEL----------IDG--LKMLLIKGIRKWHDVN-NA
LPERIIVYRDGVGDGQLKVVAGYEVQQFEECFASF-----GESY----KP
KLAVLVVQKRINTRIFSAE------PRLG--------------------N
PGPGSVLDHTVTRKDWNDFFLVSQHVRQGTVTPTHYVVVYDTSNWKPDI-
---MQKLSYKLTHLYYNWPGTVRVPAPCQYAHKLAYQVGQSIH-------
--------------------------------------------------
----GQPSQELCDRLFFL
>PIWI|sp|Q7Z3Z3|PIWL3_HUMAN
------------------------------------MPGRARTRARGRAR
RRESYQQEAPGGPRAPGSATTQEPPQLQSTPRP-----------------
------------------------------------------------LQ
EEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVF
QDLVVNTRQDMKHVKDSKT----------------------GSEGT----
----VVQLLANHFRV-ISRPQWVAYKYNVDY-KPDIEDGN----------
----------------LRTILLDQHR-RKFG-----ERHIFDG-NSLLLS
RPL-----------------------------KERRVEWLSTTKDKNIVK
ITVEFSKELTPTSPD------------CLRYYNILFRR--TFKLLDF--E
QVGRNYY-------TKKKAIQL---------------------YRHGTSL
EIWL----GYVTSVLQYEN-SI--------TLCADVSHKLL--RIETAYD
FIKRTSA-------------------------------------------
------------------------QAQTGNIREE----------------
-------------------VTNKLIGSIVLTKYN------NKTYRVDDI-
-DWKQNPEDTF----------NKSDGS-KITYIDYYRQQHKEIVTVKKQP
LLVSQGRWKKGLTGTQREP-ILLIPQLCHM--TGLTDEICKDYSIVKELA
KHTRLSPRRRHHTLKEFINTLQDN--KKVRELLQLWDLKF-DTNFL----
SVPGRVLKNANIVQGRR-----------------MVKANSQGDWS--REI
RE---LPLLNA--MP--LHSW---LILYSRSSH----REAMSLKGHLQSV
TAPMGITM----KPAEM-----IEVDGDANSYIDTLRKYTRPTLQMGMSC
LLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKV------
-------QARTIVTKIAQQMNCKMGGALWKV-------------------
ETDVQRTMFVGIDCFHDIVNRQK-----------SIAGFVASTNAELTK-
--WYSQCVIQKTGEEL----------VKE--LEICLKAALDVWCKNE-SS
MPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTI-----SPN-----NF
TLAFIVVKKRINTRFFLKHG-----SNFQ--------------------N
PPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDT-
---VQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIH-------
--------------------------------------------------
----QEPNRSLSTRLFYL
>PIWI|sp|Q96J94|PIWL1_HUMAN
--------------------------------------MTGRARARARGR
ARGQETAQLVGSTASQQPGYIQPRPQPPPAEGE-----------------
--------------------------------------------------
------------LFGRGRQRGTAGGTAKSQGLQISAGFQELSLAERGGRR
RDFHDLGVNTRQNLDHVKESKT-------------------GSSGI----
----IVRLSTNHFRLTS-RPQWALYQYHIDY-NPLMEARR----------
----------------LRSALLFQHE-DLIG-----KCHAFDG-TILFLP
KRL-----------------------------QQKVTEVFSKTRNGEDVR
ITITLTNELPPTSPT------------CLQFYNIIFRR--LLKIMNL--Q
QIGRNYY-------N--------PN---DPI------------DIPSHRL
VIWP----GFTTSILQYEN-SI--------MLCTDVSHKVL--RSETVLD
FMFNFYH-------------------------------------------
------------------------QTEEHKFQEQ----------------
-------------------VSKELIGLVVLTKYN------NKTYRVDDI-
-DWDQNPKSTF----------KKADGS-EVSFLEYYRKQYNQEITDLKQP
VLVSQPKRRRGPGGTLPGP-AMLIPELCYL--TGLTDKMRNDFNVMKDLA
VHTRLTPEQRQREVGRLIDYIHKN--DNVQRELRDWGLSF-DSNLL----
SFSGRILQTEKIHQGGK----------------TFDYNPQFADWS--KET
RG---APLISV--KP--LDNW---LLIYTRRNY----EAANSLIQNLFKV
TPAMGMQM----RKAIM-----IEVDDRTEAYLRVLQQKVTA-------D
TQI--VVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVARTLGKQQ-----
-------TVMAIATKIALQMNCKMGGELWRV-------------------
DIPLKLVMIVGIDCYHDMTAGRR-----------SIAGFVASINEGMTR-
--WFSRCIFQDRGQEL----------VDG--LKVCLQAALRAWNSCN-EY
MPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSI-----GRGY----NP
RLTVIVVKKRVNTRFFAQSG-----GRLQ--------------------N
PLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDH-
---IQRLTYKLCHIYYNWPGVIRVPAPCQYAHKLAFLVGQSIH-------
--------------------------------------------------
----REPNLSLSNRLYYL
>PIWI|tr|A7RFC2|A7RFC2_NEMVE
----------------------------------------MTGRARGRAR
GRGRSEAAQPGGADAARRPGEPQPATGRGRSRG-----------------
--------------------------------------------------
---------------PPAGAVGVGPPKPQPPPQQVAPPTQ-QMAAMSVEP
RGAEPEERRERREYGSEPTTRRDGFNKE-------------GSVGT----
----KVGIVSNYFRLET-RPQAAIYQYNVSF-SPEVDFKK----------
----------------ARFALIGEQR-ELLG-----NIRAFDG-MVLFLP
KKLPDQV-------------------------TKIMAVRTRRETPDEPVE
ITITLTNELPADSPT------------CLHLFNIILKR--ILKYIDM--K
QVGRNYY-------YIKNAI-----------------------AIPKHGL
ELWP----GYTTSILKYEH-SI--------LLGADVSHKVL--RKQTVLD
FLYELYN-------------------------------------------
-----------------------KMQGRGNFHDE----------------
-------------------AAKKLVGEIVLTRYN------NKTYRVDDI-
-DWNKRPNSTF------------TTPKGEISFNDYYKKNYDFTITDQEQP
LLFSKPKKRKGADDP-----VLLLPELCFL--TGLSDDMRADFSVMKDLA
VHTRLDPKARSKDLNKLISEINNN--PDASGELSGWGLRF-GRNLL----
DFDGRILPGEKIFQKNK----------------GSNYDPKSADWS--REI
RG---APLHST--VN--LENW---VIVHTNRDSGV----ATDFQQTLARV
CGPMGINT----TKPRM----VPLNDDRTDSYLKALSNEIQA------DF
PQI--VVTIVPSNRKDRYDSIKKLCCLEKGVPSQVVVSRTLSKKQ-----
-------MLMSVCTKIGIQLNCKLGGEAWAV-------------------
DIPLKNLMIVGIDTYHDSSQKGR-----------SVGGFVASLNKPCTRQ
REYYSRCTFQHSGQEL----------VDG--LKVCMTAALRQWQQIN-GV
LPDKIIVFRDGVGDGQLRAVIEHEVPQILSTFKQF-----QDGY----DP
KFGFTVVKKRIQTRLFMREARDPDMRNLM--------------------N
PPPGTVVDKEVTRSEWFDFFIVSQSVRQGTVSPTHYNVIHDTTGLRPDH-
---WQQLSYKLTHLYYNWPGTVRVPAPCQYAHKLAFLVGQSLH-------
--------------------------------------------------
----KEPSLKLADKLYFL
>AGO|ALG-3_ce_
---------------------------------------------MSRRN
ATNFVDNNTLTSSGISGSGSLSPPITSRPASGQ-----------------
--------------------------------------------------
-------------ASPLSSNGSLSPPVDDQG----------SVSYNSDSP
RDLSPLLLSELACLNMREVVARPGL----------------GTIGR----
----KIPVKSNFFAVDLKNPKMVVVQYHVEVHHPGCRKLD----------
----------KDEMRIIFWKAVSDHP-NIFHN-K--FALAYDGAHQLYTV
ARLEFPDDQGSVR---LDCEATLPKDNRDRT-RCAISIQNVGP---VLLE
MQRTRTNNLDERVLT------------PIQILDIICRQ--SLT-CPL--L
KNSANFY-------TWKSSCYRIPT----------AAGQA---LDLEGGK
EMWT----GFFSSAHIASN-YR-----P--LLNIDVAHTAFYKTRITVLQ
FMCDVLNERTSKPNRNNPR---GPGAPGGYRGGRGGARGGSYQNFGNRGP
PGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRI----------------
-------------------FGDSIRGMKIRATHR------PNAIRVYKVN
SLQLPADKLMF----QGIDEEG--RQV-VCSVADYFSEKYG-PLKYPKLP
CLHVGPPTRN----------IFLPMEHCLI-DSPQKYNKKMTEKQTSAII
KAAAVDATQREDRIKQLAAQASFG----TDPFLKEFGVAV-SSQMI----
ETSARVIQPPPIMFGGNN------------RSINPVVFPKDGSW----SM
DH---QTLYMP--AT--CRSYS--MIALVDPRDQT---SLQTFCQSLTMK
ATAMGMNF----PRWPD-LVKYGRSKEDVCTLFTEIADEYRV---TNTVC
DC---IIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSR-------
-------PTPATCANIILKLNMKMGGINSRI-----------VADQITNK
YLVDQPTMVVGIDVTHPTQAEMR-------MNMPSVAAIVANVDLLPQS-
--YGANVKVQKKCRES----------VVY--LLDAIRERIITFYRHT-KQ
KPARIIVYRDGVSEGQFSEVLREEIQSIRTACLAI-----AEDF----RP
PITYIVVQKRHHARIFCKFP-NDMVGKAK--------------------N
VPPGTTVDTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADE-
---IQNITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHIKRKLGLAD
NNDCDTNSLSSSLASLLNVRTGSGKGKKSHAPSVDDESYS-LPDAASDQI
LQDCVSVAADFKSRMYFI
>AGO|ALG-4_ce_
---------------------------------------------MSRRN
ATSFVDNNTLTSSGISGSGSMSPPITSRPASGQ-----------------
--------------------------------------------------
-------------ASPLTSNGSLSPPQYADDQG--------SVSYNLDSP
RDLSPLLLSELACLNMREVVARPGL----------------GTIGR----
----QIPVKSNFFAMDLKNPKMVVIQYHVEIHHPGCRKLD----------
----------KDEMRIIFWKAVSDHP-NIFHNK---FALAYDGAHQLYTV
ARLEFPDDQGSVR---LDCEASLPKDNRDRT-RCAISIQNVGP---VLLE
MQRTRTNNLDERVLT------------PIQILDIICRQ---SLTCPL--L
KNSANFY-------TWKSSCYRIPT----------AAGQA---LDLEGGK
EMWT----GFFSSAHIASN-YR-----P--LLNIDVAHTAFYKTRITVLQ
FMCDVLNERTSKPNRNNPRGPGGPGGPGGYRGGRGGGRGGSYGNFGNRGP
PGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRI----------------
-------------------FGDAIRGMKIRAAHR------PNAIRVYKVN
SLQLPADKLMF----QGIDEEG--RQV-VCSVADYFSEKYG-PLKYPKLP
CLHVGPPTRN----------IFLPMEHCLI-DSPQKYNKKMSEKQTSAII
KAAAVDATQREDRIKQLAAQASFG----TDPFLKEFGVAV-SSQMI----
QTTARVIQPPPIMFGGN--N----------RSVNPVVFPKDGSW----TM
DN---QTLYMP--AT--CRSYS--MIALVDPRDQT---SLQTFCQSLTMK
ATAMGMNF----PRWPD-LVKYGRSKEDVCTLFTEIADEYRV----TNTV
CDC--IIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSR-------
-------PTPATCANIVLKLNMKMGGINSRI-----------VADKITNK
YLVDQPTMVVGIDVTHPTQAEMR-------MNMPSVAAIVANVDLLPQS-
--YGANVKVQKKCRES----------VVY--LLDAIRERIITFYRHT-KQ
KPARIIVYRDGVSEGQFSEVLREEIQSIRTACLAI-----AEDF----RP
PITYIVVQKRHHARIFCKYQ-NDMVGKAK--------------------N
VPPGTTVDTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADE-
---IQSITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHVKRKLGLAD
NNDCDTNSRSSTLASLLNVRTGSGKGKKSYAPSVDDESYS-LSDATSDQI
LQDCVSVATDFKSRMYFI
>AGO|ALG-5_ce
---------------------------------------MEDQWLLSAIY
DDDLVEKLKVRSSTSSRSTSINVPSLENEFLSS-----------------
--------------------------------------------------
-----------------SSGSRVSDDLYLHPIE--------ENREPFKLI
GKPLP------------------------------------STTGR----
----FLSLLANHFQITC--NGSIIHQYYIRF-DPDIPSKK----------
------------LNRTILRTLQEQNP-GLIE-----CPLVFDGIHTVYST
ELINVKEV--------NNSVINVAGVVNTKE-SPNLFKLYLTHVDSFLLD
TKIITGNQDQNQKLR------------MMHAIDTVFRQ---TSTGNF--H
AVLQSFF-------SIAQNSAIEPS---HGLGWGT--------VNLGVGR
EVCY----GFYQNVVETFD-TL--------TMNLDVATTTFY-RPVALVE
FLAEILE-------------------------------------------
---------------VPLATVTDGRSLSDVQKKK----------------
-------------------FNREVAGLKVETRHC----SCPRRFRVARC-
-TWKPTENISF----HLSETAGNQDSK-PLSLVEYYKRRYNIDLTYKHLP
CIEVGRTRE-----------CILPLELCYV-VSGQRCIKKLNEQQIANLI
RATSRNATERQNAVMSLQNRLKMD----NDVNAVKFGLKV-EAQLL----
KIEGRVLPVPRLLYRSP-NL----------KRQECVTVPNNGTW----DM
RG---KNFYSG--IQ--IREWA--IVCFASPEIIG-EASMRSFVRNLVNV
ASEIGMPF----LEEHR-FCRYAEPDQTVK-LLEHLNEQYNL--------
-QL--VLCIVP-GKSVVYGELKRK-GELLGLTTQCVRSQNVSK-------
-------ASPHTLSNLCMKINSKLGGINVIL--------------SSPPQ
SLNSEPVLFIGCHLTRSSLASSSDSTSSIAHCDSSIACLVGSMDGHPTQ-
--FSPIFRTQPRHQRT----------IVD--MCEMTREAIINFRKST-GF
KPHKIIIYRAGIADVTVDEIMQTELRAVRDACAMI-----EYGF----QP
GITFIGLDVTHHTRLFAANE-KDRVGNSQ--------------------N
VPAGTLVETGITVNNLFEFYLVSHAGIQGTSRPTKYVVMWDDNSIPSAD-
---IHEMTYQLCHTQSRCTRSVSIPSPVYYAKLVAQRAKILMA-------
---------------------------------------------DENFD
MERFRLCGIGRNDGMSFT
>AGO|tr|A7RQ46|A7RQ46_NEMVE
--------------------------------------------------
-------------MASNNPVN-----------------------------
--------------------------------------------------
-----------------------------------------RVGGNFNPP
KRPNH------------------------------------GSTGR----
----TIALRANFFPVQL--PRGNIHHYDLSI-CPDKCPRR----------
------------VNRDVVEVMVLNYH-KVFGG----MKPVFDGRKNLYTR
DPLPIGKTP-------TEFEVVLPTDNSQDK-KFKVTLKWVSQ--VSLYA
LEKALEGTCNQIPFE------------TIQALDVVLRH---LPSMKY--T
PVGRSFF-------S--------PP-----------DGYD---FPLERGR
EVWF----GFHQSIRPSQ--WK-----M--LLNIDVSATAFY-KCQSVVE
FMCEVLR-------------------------------------------
---------------IRKDDLEKHAPLNDADRLR----------------
-------------------FTREIKGLKVEITHC---GPMKRKYRVINV-
-TKQPAQALQF----PLTLESG--QTA-QITVARYFQDKHKQRLRYPHLP
CLQVGQEQRH----------TYLPLEVCNIVP-GQRCVKKLTDTQTSKMI
RATARSAPDREREIRGLVKKANFD----EDAYVKDFSISI-GKNMV----
ELQGRVLPPPKLVYGGK-------------VRIEKIIHSFSGVW----DM
RG---RQLFHG--IE--IRTWA--IACFVKQQMCT-EDSLRRFSNQLMKI
SVEQGMPI----SCPPV-FFRYARNPDEVERMFRRLKEAHPD--------
LQM--ILVVLPGKTP-VYAEVKRVGDTMLGVITQCIQGKNVTK-------
-------PSPQTLSNLCLKINAKLGGVNNIL-------------APEIRP
PVFREPVIFLGADVTHPAAGDDK---------RPSVAAVVGSMDAHPSR-
--YYASVRVQTHRQEI----------IAE--LAAMVRELLVQFYRST-RH
KPQRIVFYRDGVSEGQFRQVLVHELKAIREACIKL-----EVGY----QP
GISFIVVQKRHHTRLFCQRD-QDKCGKSG--------------------N
VPPGTTVDRGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNFSADE-
---LQALTYQLCHTYVRCTRAVSIPAPAYYAHLVAFRARYHMM-------
--------------------------DRDKEAGNDNSSVASGEDCRGPQL
LANAVQVHPKVLQGMYFA
>AGO|ALG-1_ce_
MAAELNNTNTNESSNVASNDPMSGGPQYLPGVMNSTIQQQPQSATSSFLP
SGPISSTSTSSQVVPTSGATQQPPFPSAQAAAS-----------------
---------------------TALQNDLEEIFNSPPTQPQTFSDVPQRQA
GSLAPGVPIGNTSVSIGEPANTLGGGLPGGAPGQLPGGN--QSGIQFQCP
RRPNH------------------------------------GVEGR----
----SILLRANHFAVRI--PGGTIQHYQVDV-TPDKCPRR----------
------------VNREIISCLISAFS-KYFTN----IRPVYDGKRNMYTR
EPLPIGRER-------MDFDVTLPGDSAVER-QFSVSLKWVGQ--VSLST
LEDAMEGRVRQVPFE------------AVQAMDVILRH---LPSLKY--T
PVGRSFFSPPVPNASGVMAGSCPPQASGAVAGGAHSAGQYHAESKLGGGR
EVWF----GFHQSVRPSQ--WK-----M--MLNIDVSATAFY-RSMPVIE
FIAEVLE-------------------------------------------
---------------LPVQALAERRALSDAQRVK----------------
-------------------FTKEIRGLKIEITHC---GQMRRKYRVCNV-
-TRRPAQTQTF----PLQLETG--QTI-ECTVAKYFYDKYRIQLKYPHLP
CLQVGQEQKH----------TYLPPEVCNIVP-GQRCIKKLTDVQTSTMI
KATARSAPEREREISNLVRKAEFS----ADPFAHEFGITI-NPAMT----
EVKGRVLSAPKLLYGGR---------------TRATALPNQGVW----DM
RG---KQFHTG--ID--VRVWA--IACFAQQQHVK-ENDLRMFTNQLQRI
SNDAGMPI----VGNPC-FCKYAVGVEQVEPMFKYLKQNYSG--------
IQL--VVVVLPGKTP-VYAEVKRVGDTVLGIATQCVQAKNAIR-------
-------TTPQTLSNLCLKMNVKLGGVNSIL-------------LPNVRP
RIFNEPVIFFGCDITHPPAGDSR---------KPSIAAVVGSMDAHPSR-
--YAATVRVQQHRQEI----------ISD--LTYMVRELLVQFYRNT-RF
KPARIVVYRDGVSEGQFFNVLQYELRAIREACMML-----ERGY----QP
GITFIAVQKRHHTRLFAVDK-KDQVGKAY--------------------N
IPPGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTADE-
---LQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV-------
--------------------------DREHDSGEGSQPSG-TSEDTTLSN
MARAVQVHPDANNVMYFA
>AGO|ALG-2_ce_
----------------------------------------MFPLPVHNGP
RLGKLSIFEMPGDSLTSSSFMPDGGAETSSSSQ-----------------
--------------------------------------------------
-----------------LGGSAHGAIGTKP-----------DAGVQFQCP
VRPNH------------------------------------GVEGR----
----SILLRANHFAVRI--PGGSVQHYQIDV-FPDKCPRR----------
------------VNREVIGCLISSFS-KYFTN----IRPVYDGKRNMYTR
EPLPIGTEP-------MNFEVTLPGDSAVER-KFSVTMKWIGQ--VCLSA
LDDAMEGRVRQVPHE------------AVQSIDVILRH---LPSLKY--T
PVGRSFF-------T--------PP---GVMKPGMQMHQE---SKLGGGR
EVWF----GFHQSVR-PSQ-WK-----M--MLNIDVSATAFY-RAMPVIE
FVAEVLE-------------------------------------------
---------------LPVQALAERRALSDAQRVK----------------
-------------------FTKEIRGLKIEITHC---GAVRRKYRVCNV-
-TRRPAQTQTF----PLQLETG--QTI-ECTVAKYFFDKYRIQLKYPHLP
CLQVGQEQKH----------TYLPPEVCDIVP-GQRCLKKLTDVQTSTMI
KATARSAPEREREICKLVSKAELS----ADPFAHEFGITI-NPAMT----
EVKGRVLSAPKLLYGGR--------------HRATTALPNQGVW----DM
RG---KQFHTG--ME--VRTWA--IACFAQQSHVK-ENDLRMFTTQLQRI
STDAGMPI----IGTPM-FCKYASGVEQVEPMFKYLKQTYSA--------
IQL--IVVVLPGKTP-IYAEVKRVGDTVLGIATQCVQAKNAIR-------
-------TTPQTLSNLCLKMNVKLGGVNSIL-------------LPNVRP
RIFNEPVIFLGCDITHPAAGDTR---------KPSIAAVVGSMDAHPSR-
--YAATVRVQQHRQEI----------ITD--LTYMVRELLVQFYRNT-RF
KPARIVVYRDGVSEGQLFNVLQYELRAIREACVML-----ESGY----QP
GITFIAVQKRHHTRLFAADK-ADQVGKAF--------------------N
IPPGTTVDVGITHPTEFDFFLCSHAGIQGTSRPSHYHVLWDDNDLTADE-
---LQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV-------
-------------------------DRDHGSGEEGSQPSGTSSEDTTLSS
MAKAVQVHPDSNNVMYFA
>AGO|tr|Q7KY08|Q7KY08_DROME
--------------------------MYPVGQQSQWTPSPTRPQSPSQAQ
TSFDTLTSPPAPGSSVNPTAVTSPSAQNVAAGG-----------------
-------------------------------------------------A
TVAGAAATAAQVASALGATTGSVTPAIATATPATQ------PDMPVFTCP
RRPNL------------------------------------GREGR----
----PIVLRANHFQVTM--PRGYVHHYDINI-QPDKCPRK----------
------------VNREIIETMVHAYS-KIFGV----LKPVFDGRNNLYTR
DPLPIGNER-------LELEVTLPGEGKDR--IFRVTIKWQAQ--VSLFN
LEEALEGRTRQIPYD------------AILALDVVMRH---LPSMTY--T
PVGRSFF-------S--------SP-----------EGYY---HPLGGGR
EVWF----GFHQSVRPSQ--WK-----M--MLNIDVSATAFY-KAQPVID
FMCEVLD-------------------------------------------
----------------IRDINEQRKPLTDSQRVK----------------
-------------------FTKEIKGLKIEITHC---GQMRRKYRVCNV-
-TRRPAQMQSF----PLQLENG--QTV-ECTVAKYFLDKYRMKLRYPHLP
CLQVGQEHKH----------TYLPLEVCNI-VAGQRCIKKLTDMQTSTMI
KATARSAPDREREINNLVKRADFN----NDSYVQEFGLTI-SNSMM----
EVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVW----DM
RG---KQFFTG--VE--IRIWA--IACFAPQRTVR-EDALRNFTQQLQKI
SNDAGMPI----IGQPC-FCKYATGPDQVEPMFRYLKITFPG--------
LQL--VVVVLPGKTP-VYAEVKRVGDTVLGMATQCVQAKNVNK-------
-------TSPQTLSNLCLKINVKLGGINSIL-------------VPSIRP
KVFNEPVIFLGADVTHPPAGDNK---------KPSIAAVVGSMDAHPSR-
--YAATVRVQQHRQEI----------IQE--LSSMVRELLIMFYKSTGGY
KPHRIILYRDGVSEGQFPHVLQHELTAIREACIKL-----EPEY----RP
GITFIVVQKRHHTRLFCAEK-KEQSGKSG--------------------N
IPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDE-
---LQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV-------
--------------------------EKEHDSGEGSHQSG-CSEDRTPGA
MARAITVHADTKKVMYFA
>AGO|sp|Q9UKV8|AGO2_HUMAN
--------------------------------------------------
-----------MYSGAGPALAPPAPPPP----------------------
--------------------------------------------------
-----------------------------------------IQGYAFKPP
PRPDF------------------------------------GTSGR----
----TIKLQANFFEMDI--PKIDIYHYELDI-KPEKCPRR----------
------------VNREIVEHMVQHFKTQIFGD----RKPVFDGRKNLYTA
MPLPIGRDK-------VELEVTLPGEGKDR--IFKVSIKWVSC--VSLQA
LHDALSGRLPSVPFE------------TIQALDVVMRH---LPSMRY--T
PVGRSFF-------TASEGCS----------------------NPLGGGR
EVWF----GFHQSVRPSL--WK-----M--MLNIDVSATAFY-KAQPVIE
FVCEVLD-------------------------------------------
----------------FKSIEEQQKPLTDSQRVK----------------
-------------------FTKEIKGLKVEITHC---GQMKRKYRVCNV-
-TRRPASHQTF----PLQQESG--QTV-ECTVAQYFKDRHKLVLRYPHLP
CLQVGQEQKH----------TYLPLEVCNI-VAGQRCIKKLTDNQTSTMI
RATARSAPDRQEEISKLMRSASFN----TDPYVREFGIMV-KDEMT----
DVTGRVLQPPSILYGGR---------------NKAIATPVQGVW----DM
RN---KQFHTG--IE--IKVWA--IACFAPQRQCT-EVHLKSFTEQLRKI
SRDAGMPI----QGQPC-FCKYAQGADSVEPMFRHLKNTYAG--------
LQL--VVVILPGKTP-VYAEVKRVGDTVLGMATQCVQMKNVQR-------
-------TTPQTLSNLCLKINVKLGGVNNIL-------------LPQGRP
PVFQQPVIFLGADVTHPPAGDGK---------KPSIAAVVGSMDAHPNR-
--YCATVRVQQHRQEI----------IQD--LAAMVRELLIQFYKST-RF
KPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKL-----EKDY----QP
GITFIVVQKRHHTRLFCTDK-NERVGKSG--------------------N
IPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDE-
---LQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV-------
--------------------------DKEHDSAEGSHTSG-QSNGRDHQA
LAKAVQVHQDTLRTMYFA
>AGO|sp|Q9HCK5|AGO4_HUMAN
--------------------------------------------------
-------------MEALGPG------------------------------
--------------------------------------------------
-----------------------------------------PPASLFQPP
RRPGL------------------------------------GTVGK----
----PIRLLANHFQVQI--PKIDVYHYDVDI-KPEKRPRR----------
------------VNREVVDTMVRHFKMQIFGD----RQPGYDGKRNMYTA
HPLPIGRDR-------VDMEVTLPGEGKDQ--TFKVSVQWVSV--VSLQL
LLEALAGHLNEVPDD------------SVQALDVITRH---LPSMRY--T
PVGRSFF-------S--------PP-----------EGYY---HPLGGGR
EVWF----GFHQSVRPAM--WN-----M--MLNIDVSATAFY-RAQPIIE
FMCEVLD-------------------------------------------
----------------IQNINEQTKPLTDSQRVK----------------
-------------------FTKEIRGLKVEVTHC---GQMKRKYRVCNV-
-TRRPASHQTF----PLQLENG--QAM-ECTVAQYFKQKYSLQLKYPHLP
CLQVGQEQKH----------TYLPLEVCNI-VAGQRCIKKLTDNQTSTMI
KATARSAPDRQEEISRLVKSNSMV--GGPDPYLKEFGIVV-HNEMT----
ELTGRVLPAPMLQYGGR---------------NKTVATPNQGVW----DM
RG---KQFYAG--IE--IKVWA--VACFAPQKQCR-EDLLKSFTDQLRKI
SKDAGMPI----QGQPC-FCKYAQGADSVEPMFKHLKMTYVG--------
LQL--IVVILPGKTP-VYAEVKRVGDTLLGMATQCVQVKNVVK-------
-------TSPQTLSNLCLKINAKLGGINNVL-------------VPHQRP
SVFQQPVIFLGADVTHPPAGDGK---------KPSIAAVVGSMDGHPSR-
--YCATVRVQTSRQEISQELLYSQEVIQD--LTNMVRELLIQFYKST-RF
KPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISL-----EEDY----RP
GITYIVVQKRHHTRLFCADK-TERVGKSG--------------------N
VPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE-
---LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLV-------
--------------------------DKDHDSAEGSHVSG-QSNGRDPQA
LAKAVQIHHDTQHTMYFA
>AGO|sp|Q9UL18|AGO1_HUMAN
--------------------------------------------------
-------MEAGPSGAAAGAYLP----------------------------
--------------------------------------------------
-----------------------------------------PLQQVFQAP
RRPGI------------------------------------GTVGK----
----PIKLLANYFEVDI--PKIDVYHYEVDI-KPDKCPRR----------
------------VNREVVEYMVQHFKPQIFGD----RKPVYDGKKNIYTV
TALPIGNER-------VDFEVTIPGEGKDR--IFKVSIKWLAI--VSWRM
LHEALVSGQIPVPLE------------SVQALDVAMRH---LASMRY--T
PVGRSFF-------S--------PP-----------EGYY---HPLGGGR
EVWF----GFHQSVRPAM--WK-----M--MLNIDVSATAFY-KAQPVIE
FMCEVLD-------------------------------------------
----------------IRNIDEQPKPLTDSQRVR----------------
-------------------FTKEIKGLKVEVTHC---GQMKRKYRVCNV-
-TRRPASHQTF----PLQLESG--QTV-ECTVAQYFKQKYNLQLKYPHLP
CLQVGQEQKH----------TYLPLEVCNI-VAGQRCIKKLTDNQTSTMI
KATARSAPDRQEEISRLMKNASYN----LDPYIQEFGIKV-KDDMT----
EVTGRVLPAPILQYGGR---------------NRAIATPNQGVW----DM
RG---KQFYNG--IE--IKVWA--IACFAPQKQCR-EEVLKNFTDQLRKI
SKDAGMPI----QGQPC-FCKYAQGADSVEPMFRHLKNTYSG--------
LQL--IIVILPGKTP-VYAEVKRVGDTLLGMATQCVQVKNVVK-------
-------TSPQTLSNLCLKINVKLGGINNIL-------------VPHQRS
AVFQQPVIFLGADVTHPPAGDGK---------KPSITAVVGSMDAHPSR-
--YCATVRVQRPRQEI----------IED--LSYMVRELLIQFYKST-RF
KPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKL-----EKDY----QP
GITYIVVQKRHHTRLFCADK-NERIGKSG--------------------N
IPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADE-
---LQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLV-------
--------------------------DKEHDSGEGSHISG-QSNGRDPQA
LAKAVQVHQDTLRTMYFA
>AGO|sp|Q9H9G7|AGO3_HUMAN
--------------------------------------------------
----------MEIGSAGPAGAQP---------------------------
--------------------------------------------------
---------------------------------------------LLMVP
RRPGY------------------------------------GTMGK----
----PIKLLANCFQVEI--PKIDVYLYEVDI-KPDKCPRR----------
------------VNREVVDSMVQHFK-VTIFGD---RRPVYDGKRSLYTA
NPLPVATTG-------VDLDVTLPGEGGKDR-PFKVSIKFVSR--VSWHL
LHEVLTGRTLPEPLEL----DKPISTNPVHAVDVVLRH---LPSMKY--T
PVGRSFF-------S--------AP-----------EGYD---HPLGGGR
EVWF----GFHQSVR-PAM-WK-----M--MLNIDVSATAFY-KAQPVIQ
FMCEVLD-------------------------------------------
----------------IHNIDEQPRPLTDSHRVK----------------
-------------------FTKEIKGLKVEVTHC---GTMRRKYRVCNV-
-TRRPASHQTF----PLQLENG--QTV-ERTVAQYFREKYTLQLKYPHLP
CLQVGQEQKH----------TYLPLEVCNI-VAGQRCIKKLTDNQTSTMI
KATARSAPDRQEEISRLVRSANYE----TDPFVQEFQFKV-RDEMA----
HVTGRVLPAPMLQYGGR---------------NRTVATPSHGVW----DM
RG---KQFHTG--VE--IKMWA--IACFATQRQCR-EEILKGFTDQLRKI
SKDAGMPI----QGQPC-FCKYAQGADSVEPMFRHLKNTYSG--------
LQL--IIVILPGKTP-VYAEVKRVGDTLLGMATQCVQVKNVIK-------
-------TSPQTLSNLCLKINVKLGGINNIL-------------VPHQRP
SVFQQPVIFLGADVTHPPAGDGK---------KPSIAAVVGSMDAHPSR-
--YCATVRVQRPRQEI----------IQD--LASMVRELLIQFYKST-RF
KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISL-----EKDY----QP
GITYIVVQKRHHTRLFCADR-TERVGRSG--------------------N
IPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADE-
---LQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV-------
--------------------------DKEHDSAEGSHVSG-QSNGRDPQA
LAKAVQIHQDTLRTMYFA