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HIPPO

Construction of a HIPPIE subnetwork from an input query set of proteins or interactions

Query set Input a list of proteins/interactions


Example input:
dnmt3a dnmt3b
   (this may take a while)

 Alternatively, choose a file to upload
Output parameters Output type   
 
 Layers
 


Min. number of PPIs to query set
 
   [1,Inf)
Score filter (optional) Insert a threshold on the HIPPIE confidence score
 
   [0,1] 		Or, choose predefined confidence level
 
Interaction type filter (optional) Association (MI:0914)
Physical association (MI:0915)
Direct interaction (MI:0407)
Colocalization (MI:0403)
Tissue filter (optional)
None
Adipose - Subcutaneous
Adipose - Visceral (Omentum)
Adrenal Gland
Artery - Aorta
Artery - Coronary
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex (BA24)
Brain - Caudate (basal ganglia)
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex (BA9)
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens (basal ganglia)
Brain - Putamen (basal ganglia)
Brain - Spinal cord (cervical c-1)
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - EBV-transformed lymphocytes
Cells - Transformed fibroblasts
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed (Suprapubic)
Skin - Sun Exposed (Lower leg)
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

   in  

Input of user defined filter set
                          

Alternatively, choose a file to upload
Functional filter (optional)

GO (Gene ontology) (slim)

MeSH (Medical Subject Headings)
Edge directionality (optional)

For shortest path edge direction, please, indicate sources and sinks:

Sources

  Add receptors to sources		 Sinks

  Add transcription factors to sinks
Inhibitory or activating effect (optional)

(remove score filter above to include interactions and signaling events without experimental evidence)