LCT is a tool that analyzes a protein sequence and portrays its Low Complexity Triangle with information derived from its repeatability. You can read more about the Low Complexity Triangle here. LCT follows the following steps:
  1. Split the input protein in overlapping windows of the desired length.
  2. Per window, calculate the:
    • Fraction of the most frequent amino acid
    • Minimum number of mutations to perfect repeats
  3. Represent the results in a low complexity diagram. The original one was described in PMID:30698641 (Figure 1).
Here you can see the resulting LCT for known proteins:



The following restrictions apply:
  1. At least one sequence must be submitted.
  2. The query sequence must be a valid amino acid sequence.
  3. The query sequence needs to be at least 5 amino acids longer than the selected window length.
When more than one sequence is used as input, restrictions apply for all proteins individually.


You can also download here a standalone version of the LCT tool, to run it locally. Analysis of complete proteomes or larger protein datasets can also be performed with it. It is a code written in Perl language that only needs a file in FASTA format.