sQanner is a simple web tool to evaluate the polyQ landscape of a proteome. It takes a proteome and generates a plot with the number of pure and impure polyQ, and the polyQ length distribution per threshold. A threshold is defined as the minimum number of glutamines required in a protein region of a given size to consider it a polyQ. The thresholds used in sQanner are 4/4, 4/6, 6/6, 6/8 and 8/10. The whole process takes ~10 seconds for the proteome of Saccharomyces cerevisiae (~6k proteins) and ~2 minutes for the proteome of Homo sapiens (~75k proteins).

1. Species name (to label the results):  

2. Upload its proteome, in fasta format:  

Additionally, you can download here the script to run it locally.

Cite us

Mier P, Elena-Real C, Urbanek A, Bernado P, Andrade-Navarro MA. The Importance of Definitions in the Study of polyQ Regions: A Tale of Thresholds, Impurities and Sequence Context. Comput Struct Biotechnol J 2020 Feb 4;18:306-313. doi: 10.1016/j.csbj.2020.01.012. PMID:32071707.