dAtabase of Polyx Evolution

Input & output overview

Query: ENSP00000244769

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Clustered results: Download

Ortholog's multifasta file: Download

Ortholog's alignment (fasta format): Download

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EnsemblProtein ID: ENSP00000244769 AC: P54253 UniProtID: ATX1_HUMAN Description: Ataxin-1 (Spinocerebellar ataxia type 1 protein) Gene Name: ATXN1 ATX1 SCA1

In this example, we used as query the Ensembl ID of human ataxin 1. The polyQ run of Ataxin-1 (in blue, human coordinates: 197-225), appeared in primates and seems to have grown in length during its evolution.

Ortholog's alignment simplification, showing the position of the polyX regions
polyA --- polyC --- polyD --- polyE --- polyF --- polyG --- polyH --- polyI --- polyK --- polyL --- polyM --- polyN --- polyP --- polyQ --- polyR --- polyS --- polyT --- polyV --- polyW --- polyY ---

	hsa ptr pab mmul mmu rno bta gga xtr dre dre tru tru cin cel dme	ENSP00000244769 ENSPTRP00000057036 ENSPPYP00000018177 ENSMMUP00000003929 ENSMUSP00000137439 ENSRNOP00000023140 ENSBTAP00000042169 ENSGALP00000020719 ENSXETP00000030985 ENSDARP00000134028 ENSDARP00000124202 ENSTRUP00000037418 ENSTRUP00000034401 ENSCINP00000029476 K04F10.1 FBpp0289092	1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 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--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	816 807 812 801 800 790 818 799 776 782 828 769 748 152 300 231
				*To visualize the actual sequence of a polyX, please go to the individual table of each amino acid (below). **Alignment represented in scale 1:3.

click on any graph to show the results per amino acid

polyA

*Numbers on the right refer to the maximum number of A found per window length in the regions neighboring the homorepeat (± 30 amino acids). Optional values for the different cutoffs apply, and only the homorepeats fulfilling those cutoffs will appear here. Org. EnsemblProteinID PolyX position Region position Region with polyX 4 6 8 10 12 14 16 18 20 22 hsa ENSP00000244769 158-166 128-196 QFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAE 3 4 5 5 5 6 6 6 6 6 hsa ENSP00000244769 561-568 531-598 ENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 3 4 4 4 4 5 5 5 5 6 ptr ENSPTRP00000057036 158-166 128-196 QFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAE 3 4 5 5 5 6 6 6 6 6 ptr ENSPTRP00000057036 555-562 525-592 ENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 3 4 4 4 4 5 5 5 5 6 pab ENSPPYP00000018177 158-166 128-196 QFIGSSQYSGAYASFIPSQLMPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAE 3 4 5 5 5 6 6 6 6 6 pab ENSPPYP00000018177 557-564 527-594 ENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 3 4 4 4 4 5 5 5 5 6 mmul ENSMMUP00000003929 158-166 128-196 QFIGSSQYSGTYASFIPSQLIPPAANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAE 3 4 5 5 5 6 7 7 7 7 mmul ENSMMUP00000003929 546-553 516-583 ENFNPEALVTQSAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 3 4 4 4 4 4 4 5 5 6 mmu ENSMUSP00000137439 157-165 127-195 QFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVE 3 4 5 5 5 5 5 5 6 6 rno ENSRNOP00000023140 157-165 127-195 QFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVE 3 4 5 5 5 5 5 5 6 6 rno ENSRNOP00000023140 535-542 505-572 ENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 3 4 4 4 4 5 5 5 5 6 bta ENSBTAP00000042169 562-570 532-600 ENFGPEALVTQAAYPAMVQAQIHLPVAQSVASPAAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDF 4 4 5 5 6 6 6 7 7 8 gga ENSGALP00000020719 152-162 122-192 TFQFVGPQYSGPYAGFIPSQLISPTANSATGAVAAATAVATTPSQRSQLEAYSTLLASMSGLSQQGHKVEP 3 4 5 6 7 7 8 8 8 8 xtr ENSXETP00000030985 714-721 684-751 GSRHRYAEQENGINQGSSQMASENGELRCPAAFNAAKLEPGKPLATRKRRWSAPETRKVEKFEEEPPL 2 4 4 4 4 4 5 5 5 5 tru ENSTRUP00000037418 164-170 134-200 YAGYISQMFPPPPPPPPLSSPSLTPQRPSHAAPASASPQASKHEQQRTSAVRTTMPPPPTDPVPHHV 3 4 4 5 5 5 5 5 6 6